Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/44839
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Type: Journal article
Title: A kinetic model of bone marrow neutrophil production that characterizes late phenotypic maturation
Author: Orr, Y.
Wilson, D.
Taylor, J.
Bannon, P.
Geczy, C.
Davenport, M.
Kritharides, L.
Citation: American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2007; 292(4):R1707-R1716
Publisher: Amer Physiological Soc
Issue Date: 2007
ISSN: 0363-6119
1522-1490
Statement of
Responsibility: 
Yishay Orr, David P. Wilson, Jude M. Taylor, Paul G. Bannon, Carolyn Geczy, Miles P. Davenport, and Leonard Kritharides
Abstract: Acute inflammatory stimuli rapidly mobilize neutrophils from the bone marrow by shortening postmitotic maturation time and releasing younger neutrophils; however, the kinetics of this change in maturation time remains unknown. We propose a kinetic model that examines the rate of change in neutrophil average age at exit from the bone marrow during active mobilization to quantify this response and use this model to examine the temporal profile of late neutrophil phenotypic maturation. Total and CD10–/CD16low circulating neutrophils were quantified in cardiac surgery patients during extracorporeal circulation (ECC). Net growth in the circulating neutrophil pool occurred during the procedural (0.04 ± 0.02 x 109·l–1·min–1), warming (0.14 ± 0.02 x 109·l–1·min–1), and weaning (0.12 ± 0.06 x 109·l–1·min–1) phases of ECC. When applied to our differential equation mathematical model, these results predict that neutrophil average age at exit from the bone marrow decreased continually during ECC, resulting in average neutrophil release 8.44 ± 2.20 h earlier during the weaning phase than at the beginning of ECC sampling. Modeling of concurrent changes in CD10–/CD16low neutrophil numbers indicates that CD10 expression is directly related to neutrophil mean age and predicts that the proportion of mobilizable postmitotic neutrophils that are CD10+ increases from 64 to 81% during these sampled 8.4 h of maturation.
Keywords: bone marrow; postmitotic maturation; granulopoiesis; neutrophil recruitment; mathematical modeling
Description: Copyright © 2007 by the American Physiological Society.
RMID: 0020076855
DOI: 10.1152/ajpregu.00627.2006
Published version: http://ajpregu.physiology.org/cgi/reprint/292/4/R1707
Appears in Collections:Molecular and Biomedical Science publications

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