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|Title:||Squamous cell carcinoma presenting as an orbital cyst with radiologic evidence of perineural invasion|
|Citation:||European Journal of Ophthalmology, 2007; 17(6):970-972|
|Abstract:||<h4>Purpose</h4>To report clinical and radiologic findings of cystic squamous cell carcinoma (SCC) of the orbit with evidence of perineural involvement.<h4>Methods</h4>Analysis of clinical findings and radiology with a literature review.<h4>Results</h4>A 66-year-old man with SCC of the forehead 8 years prior presented with paraesthesias, diplopia, and proptosis. Magnetic resonance imaging showed a well-defined, cystic mass of the orbit with a single, linear structure running through its center. Lateral orbitotomy revealed a cyst adherent to adjacent periorbita containing viscous, clear, yellow substance and a nerve coursing through the center. Histopathology confirmed poorly differentiated spindle cell carcinoma with positive staining for cytokeratin markers, consistent with SCC.<h4>Conclusions</h4>Orbital cysts associated with altered sensation are suggestive of SCC with perineural spread, requiring prompt investigation and treatment to minimize morbidity and mortality. The involved nerve may be seen as a single, linear structure within the mass on imaging.|
|Keywords:||Lacrimal Apparatus; Humans; Cysts; Carcinoma, Squamous Cell; Orbital Neoplasms; Cranial Nerve Neoplasms; Neoplasm Invasiveness; Diagnosis, Differential; Magnetic Resonance Imaging; Aged; Male; Keratins; Biomarkers, Tumor|
|Appears in Collections:||Medicine publications|
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