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Type: Journal article
Title: Gastric emptying is altered with the presence of gastritis
Author: Symonds, E.
Tran, C.
Butler, R.
Omari, T.
Citation: Digestive Diseases and Sciences, 2008; 53(3):636-641
Publisher: Kluwer Academic/Plenum Publishers
Issue Date: 2008
ISSN: 0163-2116
Statement of
Erin L. Symonds, Cuong D. Tran, Ross N. Butler, and Taher I. Omari
Abstract: Helicobacter pylori infection and gastritis can cause symptoms suggestive of altered gastrointestinal function; however, it is unclear if H. pylori influences gastric motility. This study assessed gastric emptying rates in mouse models of gastritis. Gastritis was induced in C57BL/6 mice via ethanol treatment or via challenge with H. pylori or H. felis. Gastric emptying rates of nutrient and non-nutrient liquids were assessed with the non-invasive 13C-breath test, and the results were compared to healthy mice. Gastric emptying of the non-nutrient liquid was unaltered with the presence of gastritis; however, gastric emptying of the nutrient liquid was accelerated after a 4-week infection with H. pylori. H. felis infection and ethanol treatment caused a more severe gastritis and disruptions to the normal gastric emptying. Changes to gastric emptying in mouse models of gastritis are associated with the presence of nutrients. Altered gastric emptying may contribute to symptoms commonly reported in humans with gastritis.
Keywords: Gastritis; Gastric emptying; Helicobacter pylori; 13C octanoic acid breath test
Provenance: First published online: 31 August 2007.
Rights: © Springer Science+Business Media, LLC 2007
RMID: 0020072307
DOI: 10.1007/s10620-007-9928-8
Appears in Collections:Paediatrics publications

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