Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/4540
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSemple, S.-
dc.contributor.authorNobbs, S.-
dc.contributor.authorPyke, S.-
dc.contributor.authorReynolds, G.-
dc.contributor.authorFlower, R.-
dc.date.issued1999-
dc.identifier.citationJournal of Ethnopharmacology, 1999; 68(1-3):283-288-
dc.identifier.issn0378-8741-
dc.identifier.issn1872-7573-
dc.identifier.urihttp://hdl.handle.net/2440/4540-
dc.description.abstractThe antipicornaviral activity of an ethanolic extract of the green aerial parts of the Australian plant Pterocaulon sphacelatum (Labill.) Benth. & Hook. f. ex F. Muell. has been investigated. This plant has been a favoured traditional medicine, used for the treatment of colds by the Australian Aboriginal people. Antiviral activity-guided fractionation of the extract of P. sphacelatum using an inhibition of poliovirus-induced cytopathic effect assay, has yielded the antiviral flavonoid chrysosplenol C (3,7,3'-trimethoxy-5,6,4'-trihydroxyflavone). This compound is a 4'-hydroxy-3-methoxyflavone, one of a group of compounds known to be potent and specific inhibitors of picornaviral replication. These compounds inhibit the replication of rhinoviruses, the most frequent causative agent of the common cold. The coumarin 6,7,8-trimethoxycoumarin was also isolated from the ethanolic extract.-
dc.description.statementofresponsibilityS.J Semple, S.F Nobbs, S.M Pyke, G.D Reynolds, R.L.P Flower-
dc.language.isoen-
dc.publisherELSEVIER SCI IRELAND LTD-
dc.rights© 1999 Elsevier Science Ireland Ltd. All rights reserved.-
dc.subjectPterocaulon sphacelatum; Asteraceae; Antiviral; Chrysosplenol C; Australian Aboriginal medicine-
dc.titleAntiviral flavanoid from Pterocaulon sphacelatum, an Australian Aboriginal medicine-
dc.typeJournal article-
dc.identifier.doi10.1016/S0378-8741(99)00050-1-
pubs.publication-statusPublished-
dc.identifier.orcidPyke, S. [0000-0002-0061-5115]-
Appears in Collections:Aurora harvest 2
Chemistry publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.