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https://hdl.handle.net/2440/45413
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Type: | Journal article |
Title: | Caspase function in programmed cell death |
Author: | Kumar, S. |
Citation: | Cell Death and Differentiation, 2007; 14(1):32-43 |
Publisher: | Nature Publishing Group |
Issue Date: | 2007 |
ISSN: | 1350-9047 1476-5403 |
Statement of Responsibility: | S Kumar |
Abstract: | The first proapoptotic caspase, CED-3, was cloned from Caenorhabditis elegans in 1993 and shown to be essential for the developmental death of all somatic cells. Following the discovery of CED-3, caspases have been cloned from several vertebrate and invertebrate species. As reviewed in other articles in this issue of Cell Death and Differentiation, many caspases function in nonapoptotic pathways. However, as is clear from the worm studies, the evolutionarily conserved role of caspases is to execute programmed cell death. In this article, I will specifically focus on caspases that function primarily in cell death execution. In particular, the physiological function of caspases in apoptosis is discussed using examples from the worm, fly and mammals. |
Keywords: | Animals Humans Caspases Apoptosis Biological Evolution |
Description: | Copyright © 2007 Nature Publishing Group. All rights reserved. |
DOI: | 10.1038/sj.cdd.4402060 |
Published version: | http://www.nature.com/cdd/journal/v14/n1/pdf/4402060a.pdf |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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