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Type: Journal article
Title: Caspase function in programmed cell death
Author: Kumar, S.
Citation: Cell Death and Differentiation, 2007; 14(1):32-43
Publisher: Nature Publishing Group
Issue Date: 2007
ISSN: 1350-9047
Statement of
S Kumar
Abstract: The first proapoptotic caspase, CED-3, was cloned from Caenorhabditis elegans in 1993 and shown to be essential for the developmental death of all somatic cells. Following the discovery of CED-3, caspases have been cloned from several vertebrate and invertebrate species. As reviewed in other articles in this issue of Cell Death and Differentiation, many caspases function in nonapoptotic pathways. However, as is clear from the worm studies, the evolutionarily conserved role of caspases is to execute programmed cell death. In this article, I will specifically focus on caspases that function primarily in cell death execution. In particular, the physiological function of caspases in apoptosis is discussed using examples from the worm, fly and mammals.
Keywords: Animals; Humans; Caspases; Apoptosis; Biological Evolution
Description: Copyright © 2007 Nature Publishing Group. All rights reserved.
RMID: 0020070014
DOI: 10.1038/sj.cdd.4402060
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Appears in Collections:Medicine publications

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