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Type: Journal article
Title: Suppression of LTP-like plasticity in human motor cortex by the GABA(B) receptor agonist baclofen
Author: McDonnell, Michelle Nadine
Orekhov, Yuri
Ziemann, U.
Citation: Experimental Brain Research, 2007; 180 (1):181-186
Publisher: Springer
Issue Date: 2007
ISSN: 0014-4819
School/Discipline: School of Molecular and Biomedical Science
Statement of
McDonnell, Michelle; Orekhov, Yuri and Ziemann, Ulf
Abstract: Previous experiments in slice preparations revealed that pharmacological activation of GABAB receptors down- or up-regulates long-term potentiation (LTP), depending on whether increase of GABAB receptor mediated inhibitory postsynaptic potentials or decrease of presynaptic auto-inhibition of GABAA receptor mediated inhibition predominates. The effects of GABAB receptor activation on LTP in humans in vivo are unknown. Here we show, by using transcranial magnetic stimulation, that the GABAB receptor agonist baclofen decreases paired associative stimulation induced LTP-like plasticity in human motor cortex. This suggests that increased GABAB mediated inhibitory postsynaptic potentials drive this effect, and that baclofen may have a negative impact on LTP-dependent behavioural processes such as motor learning.
Keywords: GABAB receptor; Baclofen; LTP-like plasticity; Paired associative stimulation; Transcranial magnetic stimulation; Human motor cortex
DOI: 10.1007/s00221-006-0849-0
Appears in Collections:Molecular and Biomedical Science publications

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