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Type: Journal article
Title: Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats
Author: Southcott, E.
Tooley, K.
Howarth, G.
Davidson, G.
Butler, R.
Citation: Digestive Diseases and Sciences, 2008; 53(7):1837-1841
Publisher: Kluwer Academic/Plenum Publ
Issue Date: 2008
ISSN: 0163-2116
Statement of
E. Southcott, K. L. Tooley, G. S. Howarth, G. P. Davidson and R. N. Butler
Abstract: Small intestinal permeability was employed to assess the efficacy of commercially available yoghurts containing probiotics in a rat model of methotrexate (MTX)-induced mucositis. Male Sprague-Dawley rats were allocated to four groups (n = 8): MTX + water, MTX + cow’s milk yoghurt (CY; fermented with Lactobacillus johnsonii), MTX + sheep’s milk yoghurt (SY; containing Lactobacillus bulgaricus and Streptococcus thermophilus), and saline. Treatment gavage occurred twice daily for 7 days pre-MTX and 5 days post-MTX. Intestinal permeability was assessed on days −7, −1, 2, and 5 of the trial. Intestinal sections were collected at sacrifice for histological and biochemical analyses. Histology revealed that rats receiving CY and SY did not have a significantly damaged duodenum compared to controls. However, an improved small intestinal barrier function was evident, determined by a decreased lactulose/mannitol ratio. Probiotics containing SY and CY may be useful in preventing disruption to intestinal barrier function in MTX-induced mucositis.
Keywords: Methotrexate; Mucositis; Small intestine; Permeability; Barrier function; Probiotics
Description: The original publication can be found at
RMID: 0020080807
DOI: 10.1007/s10620-008-0275-1
Appears in Collections:Paediatrics publications

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