Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats|
|Citation:||Digestive Diseases and Sciences, 2008; 53(7):1837-1841|
|Publisher:||Kluwer Academic/Plenum Publ|
|E. Southcott, K. L. Tooley, G. S. Howarth, G. P. Davidson and R. N. Butler|
|Abstract:||Small intestinal permeability was employed to assess the efficacy of commercially available yoghurts containing probiotics in a rat model of methotrexate (MTX)-induced mucositis. Male Sprague-Dawley rats were allocated to four groups (n = 8): MTX + water, MTX + cow’s milk yoghurt (CY; fermented with Lactobacillus johnsonii), MTX + sheep’s milk yoghurt (SY; containing Lactobacillus bulgaricus and Streptococcus thermophilus), and saline. Treatment gavage occurred twice daily for 7 days pre-MTX and 5 days post-MTX. Intestinal permeability was assessed on days −7, −1, 2, and 5 of the trial. Intestinal sections were collected at sacrifice for histological and biochemical analyses. Histology revealed that rats receiving CY and SY did not have a significantly damaged duodenum compared to controls. However, an improved small intestinal barrier function was evident, determined by a decreased lactulose/mannitol ratio. Probiotics containing SY and CY may be useful in preventing disruption to intestinal barrier function in MTX-induced mucositis.|
|Keywords:||Methotrexate; Mucositis; Small intestine; Permeability; Barrier function; Probiotics|
|Description:||The original publication can be found at www.springerlink.com|
|Appears in Collections:||Paediatrics publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.