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https://hdl.handle.net/2440/46246
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dc.contributor.author | Southcott, E. | - |
dc.contributor.author | Tooley, K. | - |
dc.contributor.author | Howarth, G. | - |
dc.contributor.author | Davidson, G. | - |
dc.contributor.author | Butler, R. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Digestive Diseases and Sciences, 2008; 53(7):1837-1841 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.issn | 1573-2568 | - |
dc.identifier.uri | http://hdl.handle.net/2440/46246 | - |
dc.description | The original publication can be found at www.springerlink.com | - |
dc.description.abstract | Small intestinal permeability was employed to assess the efficacy of commercially available yoghurts containing probiotics in a rat model of methotrexate (MTX)-induced mucositis. Male Sprague-Dawley rats were allocated to four groups (n = 8): MTX + water, MTX + cow’s milk yoghurt (CY; fermented with Lactobacillus johnsonii), MTX + sheep’s milk yoghurt (SY; containing Lactobacillus bulgaricus and Streptococcus thermophilus), and saline. Treatment gavage occurred twice daily for 7 days pre-MTX and 5 days post-MTX. Intestinal permeability was assessed on days −7, −1, 2, and 5 of the trial. Intestinal sections were collected at sacrifice for histological and biochemical analyses. Histology revealed that rats receiving CY and SY did not have a significantly damaged duodenum compared to controls. However, an improved small intestinal barrier function was evident, determined by a decreased lactulose/mannitol ratio. Probiotics containing SY and CY may be useful in preventing disruption to intestinal barrier function in MTX-induced mucositis. | - |
dc.description.statementofresponsibility | E. Southcott, K. L. Tooley, G. S. Howarth, G. P. Davidson and R. N. Butler | - |
dc.language.iso | en | - |
dc.publisher | Kluwer Academic/Plenum Publ | - |
dc.source.uri | http://dx.doi.org/10.1007/s10620-008-0275-1 | - |
dc.subject | Methotrexate | - |
dc.subject | Mucositis | - |
dc.subject | Small intestine | - |
dc.subject | Permeability | - |
dc.subject | Barrier function | - |
dc.subject | Probiotics | - |
dc.title | Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s10620-008-0275-1 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Howarth, G. [0000-0001-6979-6084] | - |
Appears in Collections: | Aurora harvest 6 Paediatrics publications |
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