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|Title:||Elevated levels of HER-2/neu and androgen receptor in clinically localized prostate cancer identifies metastatic potential|
|Citation:||Prostate, 2008; 68(8):830-838|
|Ricciardelli C, Jackson M.W, Choong C.S, Stah J, Marshall V.R, Horsfall D.J and Tilley W.D.|
|Abstract:||BACKGROUND: In this study, we investigated the expression of HER-2/neu and AR in clinically organ-confined prostate cancer to determine whether alterations in these signaling pathways contribute to the development of metastatic disease. METHODS: HER-2/neu and AR immunoreactivity were evaluated in archived prostatic tissues obtained from 53 men with clinically organ-confined disease who underwent radical prostatectomy. Associations between AR and HER-2/neu immunostaining and disease outcome were determined. RESULTS: Seventy percent (37/53) of tumors exhibited high levels of HER-2/neu immunostaining and 68% (36/53) of tumors had elevated AR levels. Patients with high levels of both HER-2/neu and AR had the highest rate of PSA failure (56%, 15/27) compared with no PSA failures amongst seven patients with low levels of both HER-2/neu and AR (log rank statistic 7.69, P = 0.021). Concurrent high levels of HER-2/neu and AR expression were significantly associated with high pathological stage (P = 0.027) and development of metastatic disease (P = 0.022). CONCLUSIONS: These findings support the notion that both the HER-2/neu and AR signaling pathways may contribute to development of metastatic disease. The subset of prostate tumors with increased HER-2/neu and AR levels may benefit from treatment strategies that target both signaling pathways.|
|Keywords:||Humans; Prostatic Neoplasms; Neoplasm Metastasis; Neoplasm Recurrence, Local; Prostate-Specific Antigen; Receptor, erbB-2; Receptors, Androgen; Prostatectomy; Immunohistochemistry; Aged; Middle Aged; Male|
|Appears in Collections:||Medicine publications|
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