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Type: Journal article
Title: Ultrasensitive gene regulation by positive feedback loops in nucleosome modification
Author: Sneppen, K.
Micheelsen, M.
Dodd, I.
Citation: Molecular Systems Biology, 2008; 4:1-5
Publisher: Nature Publishing Group
Issue Date: 2008
ISSN: 1744-4292
Statement of
Kim Sneppen, Mille A Micheelsen and Ian B Dodd
Abstract: Eukaryotic transcription involves the synergistic interaction of many different proteins. However, the question remains how eukaryotic promoters achieve ultrasensitive or threshold responses to changes in the concentration or activity of a single transcription factor (TF). We show theoretically that by recruiting a histone-modifying enzyme, a TF binding non-cooperatively to a single site can change the balance between opposing positive feedback loops in histone modification to produce a large change in gene expression in response to a small change in concentration of the TF. This mechanism can also generate bistable promoter responses, allowing a gene to be on in some cells and off in others, despite the cells being in identical conditions. In addition, the system provides a simple means by which the activities of many TFs could be integrated at a promoter.
Keywords: epigenetics; histone modification; signal integration; threshold; transcription factor
Description: Copyright © 2008, EMBO and Nature Publishing Group. This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission. This article is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Licence.
RMID: 0020080723
DOI: 10.1038/msb.2008.21
Appears in Collections:Molecular and Biomedical Science publications

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