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https://hdl.handle.net/2440/46403
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Type: | Journal article |
Title: | Deficiency of 6B11+invariant NK T-cells in celiac disease |
Author: | Grose, R. Thompson, F. Cummins, A. |
Citation: | Digestive Diseases and Sciences, 2008; 53(7):1846-1851 |
Publisher: | Kluwer Academic/Plenum Publ |
Issue Date: | 2008 |
ISSN: | 0163-2116 1573-2568 |
Statement of Responsibility: | Randall H. Grose, Fiona M. Thompson and Adrian G. Cummins |
Abstract: | Immunoregulatory NK T-cells are deficient in certain autoimmune diseases. The purpose of this study was to investigate any deficiency of immunoregulatory NK T-cells in celiac disease. NK T-cells were identified by flow cytometry with 6B11 and Vα24 markers in blood from 18 normal and 12 celiac subjects. Blood mononuclear cells were stimulated with anti-CD3/CD28 antibodies and intracellular cytokines assessed at 4 h in seven normal and eight celiac subjects. Vα24/GAPDH mRNA was quantitated in duodenal biopsies by real time PCR in 17 control and 13 celiac subjects. NK T-cells in celiac subjects were reduced to 30% of those in normal subjects. Intracellular IL-4, IL-10 and IL-13 increased significantly by 33–41% in normal subjects, but did not change in celiac subjects. Vα24/GAPDH mRNA from celiac subjects was reduced to 5% of levels in control subjects. We conclude that immunoregulatory NK T-cells are deficient in celiac disease. |
Keywords: | Celiac disease Immunoregulatory NK T-cells |
Description: | The definitive version can be found at www.springerlink.com |
DOI: | 10.1007/s10620-007-0093-x |
Published version: | http://dx.doi.org/10.1007/s10620-007-0093-x |
Appears in Collections: | Aurora harvest Medicine publications |
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