Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Ghrelin and glucagon-like peptide 1 concentrations 24-h satiety and energy and substrate metabolism during a high-protein diet and measured in a respiration chamber|
|Citation:||American Journal of Clinical Nutrition, 2006; 83(1):89-94|
|Publisher:||Amer Soc Clinical Nutrition|
|Manuela PGM Lejeune, Klaas R Westerterp, Tanja CM Adam, Natalie D Luscombe-Marsh and Margriet S Westerterp-Plantenga|
|Abstract:||Background: The mechanism of protein-induced satiety remains unclear. Objective: The objective was to investigate 24-h satiety and related hormones and energy and substrate metabolism during a high-protein (HP) diet in a respiration chamber. Design: Twelve healthy women aged 18–40 y were fed in energy balance an adequate-protein (AP: 10%, 60%, and 30% of energy from protein, carbohydrate, and fat, respectively) or an HP (30%, 40%, and 30% of energy from protein, carbohydrate, and fat, respectively) diet in a randomized crossover design. Substrate oxidation, 24-h energy expenditure (EE), appetite profile, and ghrelin and glucagon-like peptide 1 (GLP-1) concentrations were measured. Results: Sleeping metabolic rate (6.40 ± 0.47 compared with 6.12 ± 0.40 MJ/d; P < 0.05), diet-induced thermogenesis (0.91 ± 0.25 compared with 0.69 ± 0.24 MJ/d; P < 0.05), and satiety were significantly higher, and activity-induced EE (1.68 ± 0.32 compared with 1.86 ± 0.41; P < 0.05), respiratory quotient (0.84 ± 0.02 compared with 0.88 ± 0.03; P < 0.0005), and hunger were significantly lower during the HP diet. There was a tendency for a greater 24-h EE during the HP diet (P = 0.05). Although energy intake was not significantly different between the diet groups, the subjects were in energy balance during the HP diet and in positive energy balance during the AP diet. Satiety was related to 24-h protein intake (r2 = 0.49, P < 0.05) only during the HP diet. Ghrelin concentrations were not significantly different between diets. GLP-1 concentrations after dinner were higher during the HP than during the AP diet (P < 0.05). Conclusion: An HP diet, compared with an AP diet, fed at energy balance for 4 d increased 24-h satiety, thermogenesis, sleeping metabolic rate, protein balance, and fat oxidation. Satiety was related to protein intake, and incidentally to ghrelin and GLP-1 concentrations, only during the HP diet.|
|Keywords:||Satiety; high-protein diet; ghrelin; glucagon-like peptide 1; GLP-1; energy balance|
|Description:||Copyright © 2006 by The American Society for Nutrition|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.