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https://hdl.handle.net/2440/46734
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Type: | Journal article |
Title: | Microvascular effects of corticotropin-releasing hormone in human skin vary in relation to estrogen concentration during the menstrual cycle |
Author: | Clifton, V. Crompton, R. Read, M. Gibson, P. Smith, R. Wright, I. |
Citation: | Journal of Endocrinology, 2005; 186(1):69-76 |
Publisher: | Society for Endocrinology |
Issue Date: | 2005 |
ISSN: | 0022-0795 1479-6805 |
Statement of Responsibility: | V L Clifton, R Crompton, M A Read, P G Gibson, R Smith and I M R Wright |
Abstract: | Females have a significantly greater life expectancy than males, which in part may be due to the cardio-protective effects of the female sex hormone, estrogen, on vascular function. However, the sex-specific mechanisms contributing to these differences are complex and not fully understood. Previously we have reported that corticotropin-releasing hormone (CRH) has potent dilator effects in the female skin circulation via mast cell degranulation. Furthermore the dilator response to CRH was more enhanced in females than in age-matched males, suggesting that estrogens may be involved. In this study we examined whether CRH-induced dilation and endothelial cell-dependent dilation in the skin circulation of pre-menopausal females were associated with changes in estrogen during the menstrual cycle. CRH-induced dilation (1 nM) was enhanced in the presence of high circulating concentrations of estrogen and a positive correlation was identified between CRH-induced dilation and plasma estrogen concentrations. Endothelial cell-dependent dilation was examined using acetylcholine. Acetylcholine-induced dilation (1 nM) was not correlated with circulating concentrations of estrogen. These data suggest the variation in CRH-induced dilation in the skin microvasculature during the menstrual cycle may be due to estrogenic effects on mast cell function and not due to direct changes in endothelial cell function. |
Keywords: | Forearm Microcirculation Skin Humans Acetylcholine Corticotropin-Releasing Hormone Estrogens Laser-Doppler Flowmetry Iontophoresis Menstrual Cycle Regional Blood Flow Vasodilation Dose-Response Relationship, Drug Adult Female |
Rights: | © 2005 Society for Endocrinology |
DOI: | 10.1677/joe.1.06030 |
Published version: | http://dx.doi.org/10.1677/joe.1.06030 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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