Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/46734
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Type: Journal article
Title: Microvascular effects of corticotropin-releasing hormone in human skin vary in relation to estrogen concentration during the menstrual cycle
Author: Clifton, V.
Crompton, R.
Read, M.
Gibson, P.
Smith, R.
Wright, I.
Citation: Journal of Endocrinology, 2005; 186(1):69-76
Publisher: Society for Endocrinology
Issue Date: 2005
ISSN: 0022-0795
1479-6805
Statement of
Responsibility: 
V L Clifton, R Crompton, M A Read, P G Gibson, R Smith and I M R Wright
Abstract: Females have a significantly greater life expectancy than males, which in part may be due to the cardio-protective effects of the female sex hormone, estrogen, on vascular function. However, the sex-specific mechanisms contributing to these differences are complex and not fully understood. Previously we have reported that corticotropin-releasing hormone (CRH) has potent dilator effects in the female skin circulation via mast cell degranulation. Furthermore the dilator response to CRH was more enhanced in females than in age-matched males, suggesting that estrogens may be involved. In this study we examined whether CRH-induced dilation and endothelial cell-dependent dilation in the skin circulation of pre-menopausal females were associated with changes in estrogen during the menstrual cycle. CRH-induced dilation (1 nM) was enhanced in the presence of high circulating concentrations of estrogen and a positive correlation was identified between CRH-induced dilation and plasma estrogen concentrations. Endothelial cell-dependent dilation was examined using acetylcholine. Acetylcholine-induced dilation (1 nM) was not correlated with circulating concentrations of estrogen. These data suggest the variation in CRH-induced dilation in the skin microvasculature during the menstrual cycle may be due to estrogenic effects on mast cell function and not due to direct changes in endothelial cell function.
Keywords: Forearm
Microcirculation
Skin
Humans
Acetylcholine
Corticotropin-Releasing Hormone
Estrogens
Laser-Doppler Flowmetry
Iontophoresis
Menstrual Cycle
Regional Blood Flow
Vasodilation
Dose-Response Relationship, Drug
Adult
Female
Rights: © 2005 Society for Endocrinology
DOI: 10.1677/joe.1.06030
Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

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