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dc.contributor.authorClifton, V.-
dc.contributor.authorCrompton, R.-
dc.contributor.authorRead, M.-
dc.contributor.authorGibson, P.-
dc.contributor.authorSmith, R.-
dc.contributor.authorWright, I.-
dc.identifier.citationJournal of Endocrinology, 2005; 186(1):69-76-
dc.description.abstractFemales have a significantly greater life expectancy than males, which in part may be due to the cardio-protective effects of the female sex hormone, estrogen, on vascular function. However, the sex-specific mechanisms contributing to these differences are complex and not fully understood. Previously we have reported that corticotropin-releasing hormone (CRH) has potent dilator effects in the female skin circulation via mast cell degranulation. Furthermore the dilator response to CRH was more enhanced in females than in age-matched males, suggesting that estrogens may be involved. In this study we examined whether CRH-induced dilation and endothelial cell-dependent dilation in the skin circulation of pre-menopausal females were associated with changes in estrogen during the menstrual cycle. CRH-induced dilation (1 nM) was enhanced in the presence of high circulating concentrations of estrogen and a positive correlation was identified between CRH-induced dilation and plasma estrogen concentrations. Endothelial cell-dependent dilation was examined using acetylcholine. Acetylcholine-induced dilation (1 nM) was not correlated with circulating concentrations of estrogen. These data suggest the variation in CRH-induced dilation in the skin microvasculature during the menstrual cycle may be due to estrogenic effects on mast cell function and not due to direct changes in endothelial cell function.-
dc.description.statementofresponsibilityV L Clifton, R Crompton, M A Read, P G Gibson, R Smith and I M R Wright-
dc.publisherSociety for Endocrinology-
dc.rights© 2005 Society for Endocrinology-
dc.subjectCorticotropin-Releasing Hormone-
dc.subjectLaser-Doppler Flowmetry-
dc.subjectMenstrual Cycle-
dc.subjectRegional Blood Flow-
dc.subjectDose-Response Relationship, Drug-
dc.titleMicrovascular effects of corticotropin-releasing hormone in human skin vary in relation to estrogen concentration during the menstrual cycle-
dc.typeJournal article-
dc.identifier.orcidClifton, V. [0000-0002-4892-6748]-
Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

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