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Type: Journal article
Title: Corticotropin-Releasing Hormone Causes Vasodilation in Human Skin via Mast Cell-Dependent Pathways
Author: Crompton, R.
Clifton, V.
Bisits, A.
Read, M.
Smith, R.
Wright, I.
Citation: Journal of Clinical Endocrinology and Metabolism, 2003; 88(11):5427-5432
Publisher: Endocrine Society
Issue Date: 2003
ISSN: 0021-972X
Statement of
Renee Crompton, Vicki L. Clifton, Andrew T. Bisits, Mark A. Read, Roger Smith and Ian M. R. Wright
Abstract: CRH plays a central role as a mediator of the hypothalamic-pituitary-adrenal axis and stress response and is a potent vasodilator. Previously, we have shown that CRH causes a gender-specific vasodilation in human skin, although the mechanism by which CRH operates is unclear. CRH causes mast cell degranulation in rat skin. As such, histamine and other mast cell-derived factors may be indirectly responsible for the vasodilatory effects of CRH, although CRH is also known to act directly on the vasculature. CRH-induced vasodilation in human skin was examined using laser Doppler flowmetry and iontophoresis in adult females. CRH (1 nM) was administered iontophoretically to the forearm, and blood flow was measured simultaneously in the same area by laser Doppler. CRH-induced dilation of the skin microvasculature was significantly reduced in the presence of the mast cell degranulation inhibitor, sodium cromoglycate, the histamine H1-antagonist, promethazine, or the H2-antagonist, ranitidine. CRH-induced dilation was also significantly reduced in the presence of the nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester, or the cyclooxygenase inhibitor, piroxicam. These findings provide novel evidence that CRH-induced vasodilation in human skin occurs via mast cell degranulation and is principally mediated by histamine and, to a lesser extent, by prostacyclin and nitric oxide.
Keywords: Mast Cells; Skin; Humans; Nitroprusside; Promethazine; Corticotropin-Releasing Hormone; NG-Nitroarginine Methyl Ester; Receptors, Corticotropin-Releasing Hormone; Histamine H1 Antagonists; Vasodilator Agents; Enzyme Inhibitors; Cell Degranulation; Vasodilation; Middle Aged; Female
Description: Copyright © 2003 by The Endocrine Society
RMID: 0020081134
DOI: 10.1210/jc.2003-030377
Appears in Collections:Paediatrics publications

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