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Type: Journal article
Title: Biofilm formation by Propionibacterium acnes on biomaterials in vitro and in vivo: Impact on diagnosis and treatment
Author: Bayston, R.
Ashraf, W.
Barker-Davies, R.
Tucker, E.
Clement, R.
Clayton, J.
Freeman, B.
Nuradeen, B.
Citation: Journal of Biomedical Materials Research. Part A, 2007; 81(3):705-709
Publisher: John Wiley & Sons, Inc.
Issue Date: 2007
ISSN: 1549-3296
Statement of
Roger Bayston, Waheed Ashraf, Robert Barker-Davies, Emily Tucker, Rhys Clement, Juliet Clayton, Brian J.C. Freeman and Bryar Nuradeen
Abstract: Propionibacterium acnes is found increasingly as a cause of delayed infection, usually involving implanted biomaterials. Despite susceptibility to common antibiotics, such infections are very difficult to treat and usually require surgical removal of the device. Three clinical isolates of P. acnes were assessed for ability to adhere to titanium, surgical steel and silicone, with and without a plasma conditioning film. After adherence, the biomaterials were then incubated for a further 6 days and examined for biofilm development. All three isolates adhered to all three biomaterials similarly. Importantly, we were able to demonstrate biofilm formation, including production of exopolymer similar in appearance to the polysaccharide intercellular adhesin of Staphylococcus epidermidis. A case summary also demonstrated failure to eradicate P. acnes infection in a hydrocephalus shunt after prolonged treatment. The removed shunt showed obvious biofilm formation, initially obscured by exopolymer when viewed by environmental scanning electron microscopy. Biofilm development by P. acnes explains the difficulties encountered in clinical management of such infections.
Keywords: Humans; Biofilms; Propionibacterium acnes; Staphylococcus epidermidis; Prosthesis-Related Infections; Titanium; Steel; Silicones; Biocompatible Materials; Cerebrospinal Fluid Shunts; Bacterial Adhesion; Male
Description: Published in Journal of Biomedical Materials Research Part A, 2007; 81A (3):705-709 at
RMID: 0020081151
DOI: 10.1002/jbm.a.31145
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Appears in Collections:Orthopaedics and Trauma publications

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