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Type: Journal article
Title: A chromosome inversion near the KIT gene and the Tobiano spotting pattern in horses
Author: Brooks, S.
Lear, T.
Adelson, D.
Bailey, E.
Citation: Cytogenetic and Genome Research, 2007; 119(3-4):225-230
Publisher: Karger
Issue Date: 2007
ISSN: 1424-8581
Statement of
S.A. Brooks, T.L. Lear, D.L. Adelson, E. Bailey
Abstract: Tobiano is a white spotting pattern in horses caused by a dominant gene, Tobiano(TO). Here, we report TO associated with a large paracentric chromosome inversion on horse chromosome 3. DNA sequences flanking the inversion were identified and a PCR test was developed to detect the inversion. The inversion was only found in horses with the tobiano pattern, including horses with diverse genetic backgrounds, which indicated a common genetic origin thousands of years ago. The inversion does not interrupt any annotated genes, but begins approximately 100 kb downstream of the KIT gene. This inversion may disrupt regulatory sequences for the KIT gene and cause the white spotting pattern.
Keywords: Chromosomes, Mammalian; Animals; Horses; Albumins; Vitamin D-Binding Protein; Genetic Markers; Pigmentation; In Situ Hybridization, Fluorescence; Polymerase Chain Reaction; Breeding; Haplotypes; Polymorphism, Single Nucleotide; Molecular Sequence Data; Proto-Oncogene Proteins c-kit; Chromosome Inversion
Rights: Copyright © 2007 S. Karger AG, Basel
RMID: 0020082051
DOI: 10.1159/000112065
Appears in Collections:Molecular and Biomedical Science publications
Environment Institute publications

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