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|Title:||Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines|
|Citation:||Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr, 2008; 64(7):1225-1232|
|Publisher:||Pergamon-Elsevier Science Ltd|
|Abstract:||In an ongoing effort to rationally design new antimicrobials, 47 new 1,2-dioxines have been synthesised. Broad antifungal structure–activity relationships governing aromatically substituted epoxy-1,2-dioxines 2 and 3 and their parent 1,2-dioxines 1 were assessed primarily against the pathogenic yeast, Candida albicans, with haemolytic activity of selected examples also reported.|
|Description:||Copyright © 2007 Elsevier Ltd All rights reserved.|
|Appears in Collections:||Aurora harvest|
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