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Type: Journal article
Title: Enantioselective synthesis of α-fluorinated β²-amino acids
Other Titles: Enantioselective synthesis of alpha-fluorinated beta(2)-amino acids
Author: Edmonds, M.
Graichen, F.
Gardiner, J.
Abell, A.
Citation: Organic Letters, 2008; 10(5):885-887
Publisher: Amer Chemical Soc
Issue Date: 2008
ISSN: 1523-7060
Statement of
Michael K. Edmonds, Florian H. M. Graichen, James Gardiner, and Andrew D. Abell
Abstract: A methodology for the enantioselective synthesis of α-fluorinated β²-amino acids has been developed from readily available carboxylic acids 3. Conversion to the Evan's oxazolidinone followed by enantioselective fluorination and alkylation gave 7 in high diastereomeric excess (>95%). Subsequent removal of the oxazolidinone and amination at the Bn-protected hydroxyl center gave optically active α-fluorinated β²-amino acids.
Keywords: Carboxylic Acids
Hydrocarbons, Fluorinated
Amino Acids
Molecular Structure
Description: Copyright © 2008 American Chemical Society
Provenance: Web Release Date: January 31, 2008
DOI: 10.1021/ol703045z
Published version:
Appears in Collections:Aurora harvest 6
Chemistry and Physics publications

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