Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/47893
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Type: Journal article
Title: Modelling the expected net benefits of interventions to reduce the burden of medication errors
Author: Karnon, J.
McIntosh, A.
Dean, J.
Bath, P.
Hutchinson, A.
Oakley, J.
Thomas, N.
Pratt, P.
Freeman-Parry, L.
Karsh, B.
Gandhi, T.
Tappenden, P.
Citation: Journal of Health Services Research & Policy, 2008; 13(2):85-91
Publisher: Royal Society of Medicine Press Ltd.
Issue Date: 2008
ISSN: 1355-8196
1758-1060
Statement of
Responsibility: 
Jonathan Karnon, Aileen McIntosh, Joanne Dean, Peter Bath, Allen Hutchinson, Jeremy Oakley, Nicky Thomas, Peter Pratt, Louise Freeman-Parry, Ben-Tzion Karsh, Tejal Gandhi, Paul Tappenden
Abstract: The aim of this study is to estimate the potential costs and benefits of three key interventions (computerized physician order entry [CPOE], additional ward pharmacists and bar coding) to help prioritize research to reduce medication errors.A generic model structure was developed to describe the incidence and impacts of medication errors in hospitals. The model follows pathways from medication error points at alternative stages of the medication pathway through to the outcomes of undetected errors. The model was populated from a systematic review of the medication errors literature combined with novel probabilistic calibration methods. Cost ranges were applied to the interventions, the treatment of preventable adverse drug events (pADEs), and the value of the health lost as a result of an ADE.The model predicts annual health service costs of between pound 0.3 million and pound 1 million for the treatment of pADEs in a 400-bed acute hospital in the UK. Including only health service costs, it is uncertain whether any of the three interventions will produce positive net benefits, particularly if high intervention costs are assumed. When the monetary value of lost health is included, all three interventions have a high probability of producing positive net benefits with a mean estimate of around pound 31.5 million for CPOE over a five-year time horizon.The results identify the potential cost-effectiveness of interventions aimed at medication errors, as well as identifying key drivers of cost-effectiveness that should be specifically addressed in the design of primary evaluations of medication error interventions.
Keywords: Humans; Medication Errors; Models, Theoretical; Automatic Data Processing; Pharmacists; Cost-Benefit Analysis; Medical Order Entry Systems; United Kingdom
Description: © 2008 Royal Society of Medicine Press
RMID: 0020082601
DOI: 10.1258/jhsrp.2007.007011
Published version: http://jhsrp.rsmjournals.com/cgi/content/abstract/13/2/85
Appears in Collections:Public Health publications

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