Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/47928
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Type: Journal article
Title: Antibody immobilization within glass microstructured fibers: A route to sensitive and selective biosensors
Author: Ruan, Y.
Foo, H.
Warren-Smith, S.
Hoffmann, P.
Moore, R.
Ebendorff-Heidepriem, H.
Monro, T.
Citation: Optics Express, 2008; 16(22):18514-18523
Publisher: Optical Soc Amer
Issue Date: 2008
ISSN: 1094-4087
1094-4087
Statement of
Responsibility: 
Yinlan Ruan, Tze Cheung Foo, Stephen Warren-Smith, Peter Hoffmann, Roger C. Moore, Heike Ebendorff-Heidepriem, Tanya M. Monro
Abstract: Glass microstructured optical fibers have been rendered biologically active for the first time via the immobilization of antibodies within the holes in the fiber cross-section. This has been done by introducing coating layers to the internal surfaces of soft glass fibers. The detection of proteins that bind to these antibodies has been demonstrated experimentally within this system via the use of fluorescence labeling. The approach combines the sensitivity resulting from the long interaction lengths of filled fibers with the selectivity provided by the use of antibodies.
Keywords: Glass; Antibodies; Antigen-Antibody Complex; Solutions; Biosensing Techniques; Fluorescence
Rights: © 2008 Optical Society of America
RMID: 0020082703
DOI: 10.1364/OE.16.018514
Appears in Collections:Centre of Expertise in Photonics publications
IPAS publications

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