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Type: Journal article
Title: The synthesis of (R)-(-) and (S)-(+)-Hydroxysaclofen
Author: Prager, Rolf H.
Schafer, Karl
Hamon, David P. G.
Massy-Westropp, Ralph A.
Citation: Tetrahedron, 1995; 51(42):11465-11472
Publisher: Pergamon-Elsevier Science Limited
Issue Date: 1995
ISSN: 0040-4020
School/Discipline: School of Chemistry and Physics : Chemistry
Statement of
Rolf H. Prager, Karl Schafer, David P.G. Hamon and Ralph A. Massy-Westropp
Abstract: 2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide. The epoxides were converted to (R)-(−) and (S)-(+)-hydroxysaclofen. Only the latter showed activity as a specific GABAB antagonist.
Description: Available online 29 March 2000.
Rights: Copyright © 1995 Published by Elsevier Ltd.
DOI: 10.1016/0040-4020(95)00710-P
Appears in Collections:Chemistry publications

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