Adelaide Research & Scholarship
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https://hdl.handle.net/2440/4879
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| Type: | Journal article |
| Title: | The synthesis of (R)-(-) and (S)-(+)-Hydroxysaclofen |
| Author: | Prager, Rolf H. Schafer, Karl Hamon, David P. G. Massy-Westropp, Ralph A. |
| Citation: | Tetrahedron, 1995; 51(42):11465-11472 |
| Publisher: | Pergamon-Elsevier Science Limited |
| Issue Date: | 1995 |
| ISSN: | 0040-4020 |
| School/Discipline: | School of Chemistry and Physics : Chemistry |
| Statement of Responsibility: | Rolf H. Prager, Karl Schafer, David P.G. Hamon and Ralph A. Massy-Westropp |
| Abstract: | 2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide. The epoxides were converted to (R)-(−) and (S)-(+)-hydroxysaclofen. Only the latter showed activity as a specific GABAB antagonist. |
| Description: | Available online 29 March 2000. |
| Rights: | Copyright © 1995 Published by Elsevier Ltd. |
| DOI: | 10.1016/0040-4020(95)00710-P |
| Appears in Collections: | Chemistry publications |
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