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Type: Journal article
Title: Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury
Author: Burcham, P.
Kaminskas, L.
Tan, D.
Pyke, S.
Citation: Mini - Reviews in Medicinal Chemistry, 2008; 8(4):319-330
Publisher: Bentham Science Publishers Ltd.
Issue Date: 2008
ISSN: 1389-5575
Abstract: This mini-review highlights the chemical and cytoprotective properties of various hydralazine analogues that block the induction of cell death by acrolein, a highly toxic contributor to “carbonyl stress” during a diverse range of human diseases. Recent work on the action of hydralazine against various carbonyl-mediated pathologies is also reviewed.
Keywords: Animals; Humans; Liver Diseases, Alcoholic; Alzheimer Disease; Spinal Cord Injuries; Acrolein; Hydralazine; Free Radical Scavengers; Protective Agents; Cell Death; Oxidative Stress; Atherosclerosis
RMID: 0020080742
DOI: 10.2174/138955708783955953
Appears in Collections:Chemistry and Physics publications

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