Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/50672
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Type: Journal article
Title: Cardiovascular magnetic resonance-derived aortic distensibility: validation and observed regional differences in the elderly
Author: Nelson, A.
Worthley, S.
Cameron, J.
Willoughby, S.
Piantadosi, C.
Carbone, A.
Dundon, B.
Leung, M.
Hope, S.
Meredith, I.
Worthley, M.
Citation: Journal of Hypertension, 2009; 27(3):535-542
Publisher: Lippincott Williams & Wilkins
Issue Date: 2009
ISSN: 0263-6352
1473-5598
Statement of
Responsibility: 
Nelson, Adam J; Worthley, Stephen G; Cameron, James D; Willoughby, Scott R; Piantadosi, Cynthia; Carbone, Angelo; Dundon, Benjamin K; Leung, Michael C; Hope, Sarah A; Meredith, Ian T; Worthley, Matthew I
Abstract: Objective: Applanation tonometry evaluation of pulse wave velocity is widely accepted as the 'gold standard' method for noninvasively assessing arterial stiffness. Newer noninvasive tools such as cardiovascular magnetic resonance can also evaluate arterial stiffness, but have not been validated. The aim of this study was to validate cardiovascular magnetic resonance-derived aortic distensibility with pulse wave velocity and to investigate age-related changes in regional aortic distensibility. Methods: Ten young (20-30 years) and ten old (60-70 years) patients underwent applanation tonometry assessment of pulse wave velocity. Cardiovascular magnetic resonance measurements of arterial stiffness were evaluated by aortic distensibility (10-3 mmHg-1) at three separate locations, the ascending aorta, proximal descending aorta and distal descending aorta. Results: Pulse wave velocity correlated strongly with aortic distensibility measurements at each site: ascending aorta R2 = 0.57, proximal descending aorta R2 = 0.60 and distal descending aorta R2 = 0.72. As expected, the old cohort had significantly increased aortic stiffness compared with the young cohort (P < 0.01). Post-hoc comparison showed an increase in proximal stiffness in the old cohort compared with the young cohort (P = 0.018). Conclusion: Cardiovascular magnetic resonance-derived aortic distensibility is an accurate measure of arterial stiffness and can evaluate regional stiffness through the aorta. Furthermore, our results suggest that aortic stiffening may preferentially occur in the proximal aortic segments in the elderly.
Keywords: Aorta; Aorta, Thoracic; Humans; Cardiovascular Diseases; Magnetic Resonance Imaging; Blood Flow Velocity; Blood Pressure Determination; Data Interpretation, Statistical; Reproducibility of Results; Manometry; Blood Pressure; Systole; Elasticity; Pulsatile Flow; Adult; Aged; Middle Aged; Female; Male
Description: © 2009 Lippincott Williams & Wilkins, Inc.
RMID: 0020090512
DOI: 10.1097/HJH.0b013e32831e4599
Appears in Collections:Medicine publications

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