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Type: Journal article
Title: The efficacy of a novel chitosan gel on hemostasis after endoscopic sinus surgery in a sheep model of chronic rhinosinusitis
Author: Valentine, R.
Athanasiadis, T.
Moratti, S.
Robinson, S.
Wormald, P.
Citation: American Journal of Rhinology and Allergy, 2009; 23(1):71-75
Publisher: Ocean Side Publications Inc
Issue Date: 2009
ISSN: 1945-8924
Statement of
Valentine Rowan, Athanasiadis, Theo, Moratti Stephen, Robinson, Simon and Wormald, Peter-John
Abstract: Background: Postoperative bleeding remains a major problem after endoscopic sinus surgery (ESS). Patients who continue to bleed after ESS are at risk of airway compromise from inhalation of blood clots or from aspiration of blood-stained vomitus. The aim of this study was to determine the in vivo efficacy of a novel gel on hemostasis after ESS in a sheep model of chronic rhinosinusitis. Methods: Twenty-one sheep infested with Oestrus ovus underwent ESS with standardized mucosal injuries created at the anterior ethmoid region using a microdebrider. Immediately after injury a baseline bleeding time was taken using the Boezaart Surgical Field Grading Scale. Computer randomization was performed to either receive chitosan/dextran (CD) gel or no treatment (control). Boezaart bleeding scores were calculated for each side every 2 minutes. Each postoperative day videoendoscopy was performed to document crusting/CD gel dissolution. Results: The CD gel side was significantly more hemostatic at 2, 4, and 6 minutes after injury. Average time to hemostasis was significantly better for the intervention side versus control side, 4.09 (±1.61) versus 6.57 (±2.20), respectively (p = 0.049). Complete hemostasis occurred by 6 minutes for all CD gel sides; however, control side bleeding was noted on three sides at 8 minutes and on one side at 10 minutes. There was no significant difference in crusts scores at days 1, 3, 7, and 14. Conclusion: In the sheep model of ESS, CD gel significantly improved hemostasis compared with the control at 2, 4, and 6 minutes after mucosal injury. Articles that cite this article?
Keywords: Chitosan
chronic rhinosinusitis
endoscopic sinus surgery
gel application
wound healing
Description: Website © 2009 Ingenta. Article copyright remains with the publisher, society or author(s) as specified within the article
DOI: 10.2500/ajra.2009.23.3266
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Appears in Collections:Aurora harvest
Surgery publications

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