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https://hdl.handle.net/2440/50681
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DC Field | Value | Language |
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dc.contributor.author | Valentine, R. | - |
dc.contributor.author | Athanasiadis, T. | - |
dc.contributor.author | Moratti, S. | - |
dc.contributor.author | Robinson, S. | - |
dc.contributor.author | Wormald, P. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | American Journal of Rhinology and Allergy, 2009; 23(1):71-75 | - |
dc.identifier.issn | 1945-8924 | - |
dc.identifier.issn | 1945-8932 | - |
dc.identifier.uri | http://hdl.handle.net/2440/50681 | - |
dc.description | Website © 2009 Ingenta. Article copyright remains with the publisher, society or author(s) as specified within the article | - |
dc.description.abstract | Background: Postoperative bleeding remains a major problem after endoscopic sinus surgery (ESS). Patients who continue to bleed after ESS are at risk of airway compromise from inhalation of blood clots or from aspiration of blood-stained vomitus. The aim of this study was to determine the in vivo efficacy of a novel gel on hemostasis after ESS in a sheep model of chronic rhinosinusitis. Methods: Twenty-one sheep infested with Oestrus ovus underwent ESS with standardized mucosal injuries created at the anterior ethmoid region using a microdebrider. Immediately after injury a baseline bleeding time was taken using the Boezaart Surgical Field Grading Scale. Computer randomization was performed to either receive chitosan/dextran (CD) gel or no treatment (control). Boezaart bleeding scores were calculated for each side every 2 minutes. Each postoperative day videoendoscopy was performed to document crusting/CD gel dissolution. Results: The CD gel side was significantly more hemostatic at 2, 4, and 6 minutes after injury. Average time to hemostasis was significantly better for the intervention side versus control side, 4.09 (±1.61) versus 6.57 (±2.20), respectively (p = 0.049). Complete hemostasis occurred by 6 minutes for all CD gel sides; however, control side bleeding was noted on three sides at 8 minutes and on one side at 10 minutes. There was no significant difference in crusts scores at days 1, 3, 7, and 14. Conclusion: In the sheep model of ESS, CD gel significantly improved hemostasis compared with the control at 2, 4, and 6 minutes after mucosal injury. Articles that cite this article? | - |
dc.description.statementofresponsibility | Valentine Rowan, Athanasiadis, Theo, Moratti Stephen, Robinson, Simon and Wormald, Peter-John | - |
dc.language.iso | en | - |
dc.publisher | Ocean Side Publications Inc | - |
dc.source.uri | http://dx.doi.org/10.2500/ajra.2009.23.3266 | - |
dc.subject | Chitosan | - |
dc.subject | chronic rhinosinusitis | - |
dc.subject | dextran | - |
dc.subject | endoscopic sinus surgery | - |
dc.subject | gel application | - |
dc.subject | hemostasis | - |
dc.subject | sheep | - |
dc.subject | wound healing | - |
dc.title | The efficacy of a novel chitosan gel on hemostasis after endoscopic sinus surgery in a sheep model of chronic rhinosinusitis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.2500/ajra.2009.23.3266 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Wormald, P. [0000-0001-7753-7277] | - |
Appears in Collections: | Aurora harvest Surgery publications |
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