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Type: Journal article
Title: Excited-State Intramolecular Hydrogen Atom Transfer and Solvation Dynamics of the Medicinal Pigment Curcumin
Author: Adhikary, R.
Mukherjee, P.
Kee, T.
Petrich, J.
Citation: The Journal of Physical Chemistry B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter, 2009; 113(15):5255-5261
Publisher: Amer Chemical Soc
Issue Date: 2009
ISSN: 1520-6106
Statement of
Ramkrishna Adhikary, Prasun Mukherjee, Tak W. Kee and Jacob W. Petrich
Abstract: The potential use of the naturally occurring yellow-orange pigment curcumin as a photodynamic therapy agent is one of the most exciting applications of this medicinal compound. Although subnanosecond spectroscopy has been used to investigate the photophysical processes of curcumin, the time resolution is insufficient to detect important and faster photoinduced processes, including solvation and excited-state intramolecular hydrogen atom transfer (ESIHT). In this study, the excited-state photophysics of curcumin is studied by means of ultrafast fluorescence upconversion spectroscopy. The results show two decay components in the excited-state kinetics with time scales of 12-20 ps and approximately 100 ps in methanol and ethylene glycol. The resulting prominent isotope effect in the long component upon deuteration indicates that curcumin undergoes ESIHT in these solvents. The short component (12-20 ps) is insensitive to deuteration, and multiwavelength fluorescence upconversion results show that this decay component is due to solvation of excited-state curcumin.
Keywords: Hydrogen
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet
Molecular Structure
Time Factors
Description: Copyright © 2009 American Chemical Society
DOI: 10.1021/jp901234z
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Appears in Collections:Aurora harvest 5
Chemistry and Physics publications
Environment Institute publications

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