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Type: Journal article
Title: A Study of the Protective Function of Acute Morphine Administration on Subsequent Posttraumatic Stress Disorder
Author: Bryant, R.
Creamer, M.
O'Donnell, M.
Silove, D.
McFarlane, A.
Citation: Biological Psychiatry, 2009; 65(5):438-440
Publisher: Elsevier Science Inc
Issue Date: 2009
ISSN: 0006-3223
Statement of
Richard A. Bryant, Mark Creamer, Meaghan O'Donnell, Derrick Silove and Alexander C. McFarlane
Abstract: Background To index the extent to which acute administration of morphine is protective against development of posttraumatic stress disorder (PTSD). Methods Consecutive patients admitted to hospital after traumatic injury (n = 155) were assessed for current psychiatric disorder, pain, and morphine dose in the initial week after injury and were reassessed for PTSD and other psychiatric disorders 3 months later (n = 120). Results Seventeen patients (14%) met criteria for PTSD at 3 months. Patients who met criteria for PTSD received significantly less morphine than those who did not develop PTSD; there was no difference in morphine levels in those who did and did not develop major depressive episode or another anxiety disorder. Hierarchical regression analysis indicated that PTSD severity at 3 months was significantly predicted by acute pain, mild traumatic brain injury, and elevated morphine dose in the initial 48 hours after trauma, after controlling for injury severity, gender, age, and type of injury. Conclusions Acute administration of morphine may limit fear conditioning in the aftermath of traumatic injury and may serve as a secondary prevention strategy to reduce PTSD development.
Keywords: Fear conditioning
posttraumatic stress disorder
Description: Copyright © 2009 Society of Biological Psychiatry Published by Elsevier Inc
DOI: 10.1016/j.biopsych.2008.10.032
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Psychiatry publications

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