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https://hdl.handle.net/2440/50794
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Type: | Journal article |
Title: | Combining first and second trimester markers for Down syndrome screening: Think twice |
Author: | Cocciolone, R. Brameld, K. OLeary, P. Haan, E. Muller, P. Shand, K. |
Citation: | Australian and New Zealand Journal of Obstetrics and Gynaecology, 2008; 48(5):492-500 |
Publisher: | Blackwell Publishing Asia |
Issue Date: | 2008 |
ISSN: | 0004-8666 1479-828X |
Statement of Responsibility: | Robert Cocciolone, Kate Brameld, Peter O’Leary, Eric Haan, Peter Muller, Karen Shand |
Abstract: | Aims: This study compares different screening strategies for the detection of Down syndrome and considers practical implications of using multiple screening protocols. Methods: The performance characteristics of each screening strategy were assessed based on datasets of Down syndrome (n = 11) and unaffected pregnancies (n = 1006) tested in both first and second trimester, as well as data from first trimester (n = 18 901) and second trimester (n = 40 748) pregnancies. Results: For a detection rate of 91%, the false positive rates for integrated and serum integrated screening were 2.5% and 6.3%, respectively, compared with combined first trimester (4.6%) and second trimester (12.6%) screening. Contingent and sequential screening protocols achieved detection rates of 82 to 91% with false positive rates between 2.6 and 2.9%. Contingent protocols require retesting of 15 to 20% of cases in the second trimester. Sequential and integrated protocols require retesting of 98 to 100% of cases in the second trimester. The various screening strategies did not always detect the same Down syndrome pregnancies. Conclusions: Combining first and second trimester markers for Down syndrome screening better defines the at-risk population. However, integrated protocols complicate management of screening programs and may not be suitable as primary screening strategies. It may be a better use of resources to refine current first and second trimester programs through improved access and new markers. We therefore suggest thinking twice before embracing integrated population screening programs. |
Keywords: | Down syndrome integrated contingent first trimester screening |
Rights: | © 2009 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists Copyright © 2009 John Wiley & Sons, Inc. |
DOI: | 10.1111/j.1479-828X.2008.00911.x |
Published version: | http://www3.interscience.wiley.com/journal/121476797/abstract?CRETRY=1&SRETRY=0 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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