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Type: Journal article
Title: Atacicept in patients with rheumatoid arthritis: Results of a multicenter, phase ib, double-blind, placebo-controlled, dose-escalating, single- and repeated-dose study
Author: Tak, P.
Thurlings, R.
Rossier, C.
Nestorov, I.
Dimic, A.
Mircetic, V.
Rischmueller, M.
Nasonov, E.
Shmidt, E.
Emery, P.
Munafo, A.
Citation: Arthritis and Rheumatism, 2008; 58(1):67-72
Publisher: Wiley-Liss
Issue Date: 2008
ISSN: 0004-3591
Statement of
P. P. Tak, R. M. Thurlings, C. Rossier, I. Nestorov, A. Dimic, V. Mircetic, M. Rischmueller, E. Nasonov, E. Shmidt, P. Emery and A. Munafo
Abstract: <h4>Objective</h4>Atacicept is a recombinant fusion protein that binds and neutralizes B lymphocyte stimulator and a proliferation-inducing ligand. The purpose of this study was to investigate the tolerability, pharmacokinetics, and pharmacodynamics of atacicept treatment in patients with rheumatoid arthritis (RA) and to collect exploratory data on clinical outcomes.<h4>Methods</h4>In this multicenter, phase Ib, randomized, placebo-controlled, dose-escalating trial, 73 patients were enrolled into 6 escalating-dose cohorts. Patients received atacicept or placebo as single doses (70, 210, or 630 mg) or as repeated doses given at 2-week intervals (3 doses of 70 mg, 3 doses of 210 mg, or 7 doses of 420 mg), followed by 10 weeks of trial assessments, with a followup assessment at 3 months after the final dose.<h4>Results</h4>Atacicept was well tolerated, with few differences between treatment groups and no obvious safety concerns. The pharmacokinetics profile was nonlinear, but was consistent and predictable across all doses and regimens. Treatment-related decreases in immunoglobulin (particularly IgM) and rheumatoid factor levels were evident, and a clear decrease in anti-citrullinated protein antibodies was observed in the cohort that received 7 doses of 420 mg. The B cell response was biphasic, with an initial transient increase (dominated by memory B cells) followed by a dose-related decrease (dominated by mature B cells). Clinical assessments showed trends toward improvement with the 3-month treatment. Little effect on the erythrocyte sedimentation rate or C-reactive protein levels was seen.<h4>Conclusion</h4>Atacicept was well tolerated both systemically and locally. The results demonstrated that the biologic activity of atacicept was consistent with its mechanism of action.
Keywords: Cartilage
Arthritis, Rheumatoid
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Recombinant Fusion Proteins
Antirheumatic Agents
Treatment Outcome
Flow Cytometry
Double-Blind Method
Dose-Response Relationship, Drug
Middle Aged
Description: The definitive version may be found at Copyright © 2008, American College of Rheumatology
DOI: 10.1002/art.23178
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