Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/50945
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Validity of medication-based co-morbidity indices in the Australian elderly population |
Author: | Vitry, A. Wong, S. Roughead, E. Ramsay, E. Barratt, J. |
Citation: | Australian and New Zealand Journal of Public Health, 2009; 33(2):126-130 |
Publisher: | Public Health Assoc Australia Inc |
Issue Date: | 2009 |
ISSN: | 1326-0200 1753-6405 |
Statement of Responsibility: | Agnes Vitry, Soo Ann Wong, Elizabeth E. Roughead, Emmae Ramsay, John Barratt |
Abstract: | <h4>Objectives</h4>To determine the validity of two medication-based co-morbidity indices, the Medicines Disease Burden Index (MDBI) and Rx-Risk-V in the Australian elderly population.<h4>Methods</h4>In Phase I, the sensitivity and specificity of both indices were determined in 767 respondents from wave 6 of the Australian Longitudinal Study of Ageing (ALSA). Medication-defined index disease categories were compared to self-reported medical conditions. Correlation with self-rated health was examined and Cox proportional hazards models were used to assess the predictive validity for mortality. Phase II verified the predictive ability of Rx-Risk-V in a sample of 213,191 veterans from Australian Department of Veterans' Affairs (DVA) database.<h4>Results</h4>MDBI and Rx-Risk-V scores could be calculated for 28% and 73% of the ALSA sample respectively. Both indices had high specificities and low to moderate sensitivities compared to self-reported medical conditions. Total weighted scores were significantly related to self-rated health (p<0.001). Both indices were predictive of mortality (Hazard Ratio (HR) =3.690 (95% CI 2.264-6.015) for MDBI and HR 1.079 (95% CI 1.045-1.114) for Rx-Risk-V. The predictive validity for mortality of Rx-Risk-V was confirmed using DVA data (HR= 1.090, 95% CI 1.088-1.092).<h4>Conclusions</h4>Medication-based co-morbidity indices Rx-Risk-V and MDBI are valid measures of co-morbidity. However, Rx-Risk-V detects more comorbidity in the Australian elderly population and is likely to be a more suitable index to use in administrative datasets, particularly where studies include large numbers of outpatients. |
Keywords: | co-morbidity chronic disease/drug therapy drug prescriptions risk adjustment/methods |
Description: | © 2009 The Authors. Journal Compilation © 2009 Public Health Association of Australia |
DOI: | 10.1111/j.1753-6405.2009.00357.x |
Published version: | http://dx.doi.org/10.1111/j.1753-6405.2009.00357.x |
Appears in Collections: | Aurora harvest Public Health publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.