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Type: Journal article
Title: Diverse molecular pathways in ovarian cancer and their clinical significance
Author: Ricciardelli, C.
Oehler, M.
Citation: Maturitas, 2009; 62(3):270-275
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2009
ISSN: 0378-5122
Statement of
Carmela Ricciardelli, Martin K. Oehler
Abstract: The origin of epithelial ovarian cancer remains unknown. It is believed to develop from ovarian surface epithelium, post-ovulatory inclusion cysts, endometriosis and more recently the fimbrial end of the fallopian tube. Molecular evidence suggests that ovarian cancer may progress both through a step-wise mutation process (low-grade pathway, type I), and a separate pathway with high genetic instability leading to rapid metastasis without an identifiable precursor lesion (high-grade pathway, type II). This sub-classification explains the clinical and biological heterogeneity of ovarian cancer and highlights the importance for developing novel diagnostics and therapeutics targeting two unique diseases-type I and type II ovarian carcinomas. This article summarises current knowledge of the aetiology and molecular basis of ovarian cancer and discusses recent clinical strategies for type I and type II disease.
Keywords: BRCA
Early detection
Fallopian tube
Molecular pathology
Ovarian cancer
PARP inhibitors
Peritoneal cancer
Two-pathway concept
Description: Copyright © 2009 Elsevier Ireland Ltd All rights reserved.
DOI: 10.1016/j.maturitas.2009.01.001
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Appears in Collections:Aurora harvest 5
Obstetrics and Gynaecology publications

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