Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/51056
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Type: Journal article
Title: Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial
Author: Smithers, L.
Gibson, R.
McPhee, A.
Makrides, M.
Citation: American Journal of Clinical Nutrition, 2008; 88(4):1049-1056
Publisher: Amer Soc Clinical Nutrition
Issue Date: 2008
ISSN: 0002-9165
1938-3207
Statement of
Responsibility: 
Lisa G Smithers, Robert A Gibson, Andrew McPhee, and Maria Makrides
Abstract: Preterm infants have improved visual outcomes when fed a formula containing 0.2-0.4% docosahexaenoic acid (DHA) compared with infants fed no DHA, but the optimal DHA dose is unknown.We assessed visual responses of preterm infants fed human milk (HM) and formula with a DHA concentration estimated to match the intrauterine accretion rate (high-DHA group) compared with infants fed HM and formula containing DHA at current concentrations.A double-blind randomized controlled trial studied preterm infants born at <33 wk gestation and fed HM or formula containing 1% DHA (high-DHA group) or approximately 0.3% DHA (current practice; control group) until reaching their estimated due date (EDD). Both groups received the same concentration of arachidonic acid. Sweep visual evoked potential (VEP) acuity and latency were assessed at 2 and 4 mo corrected age (CA). Weight, length, and head circumference were assessed at EDD and at 2 and 4 mo CA.At 2 mo CA, acuity of the high-DHA group did not differ from the control group [high-DHA group (x +/- SD): 5.6 +/- 2.4 cycles per degree (cpd), n = 54; control group: 5.6 +/- 2.4 cpd, n = 61; P = 0.96]. By 4 mo CA, the high-DHA group exhibited an acuity that was 1.4 cpd higher than the control group (high-DHA: 9.6 +/- 3.7 cpd, n = 44; control: 8.2 +/- 1.8 cpd; n = 51; P = 0.025). VEP latencies and anthropometric measurements were not different between the high-DHA and control groups.The DHA requirement of preterm infants may be higher than currently provided by preterm formula or HM of Australian women.
Keywords: Milk, Human; Humans; Body Weight; Birth Weight; Docosahexaenoic Acids; Body Height; Double-Blind Method; Nutritional Requirements; Evoked Potentials, Visual; Visual Acuity; Dose-Response Relationship, Drug; Infant Formula; Infant, Newborn; Infant, Premature; Female; Male; Infant Nutritional Physiological Phenomena
Description: © 2008 American Society for Nutrition
RMID: 0020083050
DOI: 10.1093/ajcn/88.4.1049
Appears in Collections:Paediatrics publications

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