Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/51056
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Smithers, L. | - |
dc.contributor.author | Gibson, R. | - |
dc.contributor.author | McPhee, A. | - |
dc.contributor.author | Makrides, M. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | American Journal of Clinical Nutrition, 2008; 88(4):1049-1056 | - |
dc.identifier.issn | 0002-9165 | - |
dc.identifier.issn | 1938-3207 | - |
dc.identifier.uri | http://hdl.handle.net/2440/51056 | - |
dc.description | © 2008 American Society for Nutrition | - |
dc.description.abstract | <h4>Background</h4>Preterm infants have improved visual outcomes when fed a formula containing 0.2-0.4% docosahexaenoic acid (DHA) compared with infants fed no DHA, but the optimal DHA dose is unknown.<h4>Objective</h4>We assessed visual responses of preterm infants fed human milk (HM) and formula with a DHA concentration estimated to match the intrauterine accretion rate (high-DHA group) compared with infants fed HM and formula containing DHA at current concentrations.<h4>Design</h4>A double-blind randomized controlled trial studied preterm infants born at <33 wk gestation and fed HM or formula containing 1% DHA (high-DHA group) or approximately 0.3% DHA (current practice; control group) until reaching their estimated due date (EDD). Both groups received the same concentration of arachidonic acid. Sweep visual evoked potential (VEP) acuity and latency were assessed at 2 and 4 mo corrected age (CA). Weight, length, and head circumference were assessed at EDD and at 2 and 4 mo CA.<h4>Results</h4>At 2 mo CA, acuity of the high-DHA group did not differ from the control group [high-DHA group (x +/- SD): 5.6 +/- 2.4 cycles per degree (cpd), n = 54; control group: 5.6 +/- 2.4 cpd, n = 61; P = 0.96]. By 4 mo CA, the high-DHA group exhibited an acuity that was 1.4 cpd higher than the control group (high-DHA: 9.6 +/- 3.7 cpd, n = 44; control: 8.2 +/- 1.8 cpd; n = 51; P = 0.025). VEP latencies and anthropometric measurements were not different between the high-DHA and control groups.<h4>Conclusion</h4>The DHA requirement of preterm infants may be higher than currently provided by preterm formula or HM of Australian women. | - |
dc.description.statementofresponsibility | Lisa G Smithers, Robert A Gibson, Andrew McPhee, and Maria Makrides | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Clinical Nutrition | - |
dc.source.uri | http://dx.doi.org/10.1093/ajcn/88.4.1049 | - |
dc.subject | Milk, Human | - |
dc.subject | Humans | - |
dc.subject | Body Weight | - |
dc.subject | Birth Weight | - |
dc.subject | Docosahexaenoic Acids | - |
dc.subject | Body Height | - |
dc.subject | Double-Blind Method | - |
dc.subject | Nutritional Requirements | - |
dc.subject | Evoked Potentials, Visual | - |
dc.subject | Visual Acuity | - |
dc.subject | Dose-Response Relationship, Drug | - |
dc.subject | Infant Formula | - |
dc.subject | Infant, Newborn | - |
dc.subject | Infant, Premature | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Infant Nutritional Physiological Phenomena | - |
dc.title | Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/ajcn/88.4.1049 | - |
dc.relation.grant | NHMRC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Smithers, L. [0000-0002-6585-7836] | - |
dc.identifier.orcid | Gibson, R. [0000-0002-8750-525X] | - |
dc.identifier.orcid | McPhee, A. [0000-0003-3820-5696] | - |
dc.identifier.orcid | Makrides, M. [0000-0003-3832-541X] | - |
Appears in Collections: | Aurora harvest Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.