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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/51191
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dc.contributor.authorObando, D.-
dc.contributor.authorPantarat, N.-
dc.contributor.authorHandke, R.-
dc.contributor.authorKoda, Y.-
dc.contributor.authorWidmer, F.-
dc.contributor.authorDjordjevic, J.-
dc.contributor.authorEllis, D.-
dc.contributor.authorSorrell, T.-
dc.contributor.authorJolliffe, K.-
dc.date.issued2009-
dc.identifier.citationBioorganic and Medicinal Chemistry, 2009; 17(17):6329-6339-
dc.identifier.issn0968-0896-
dc.identifier.issn1464-3391-
dc.identifier.urihttp://hdl.handle.net/2440/51191-
dc.descriptionAvailable online 23 July 2009.-
dc.description.abstractA series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5′-nonyl) and 3-methyl,4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4–2.7 μM against reference strains of both Cryptococcus neoformans and Candida albicans.-
dc.description.statementofresponsibilityDaniel Obando, Namfon Pantarat, Rosemary Handke, Yasuko Koda, Fred Widmer, Julianne T. Djordjevic, David H. Ellis, Tania C. Sorrell and Katrina A. Jolliffe-
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/129/description#description-
dc.language.isoen-
dc.publisherPergamon-Elsevier Science Ltd-
dc.rightsCopyright © 2009 Elsevier Ltd. All rights reserved-
dc.source.urihttp://dx.doi.org/10.1016/j.bmc.2009.07.037-
dc.subjectBispyridinium-
dc.subjectAntifungal activity-
dc.subjectHaemolytic activity-
dc.subjectFungal phospholipase B-
dc.titleSynthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes-
dc.typeJournal article-
dc.identifier.doi10.1016/j.bmc.2009.07.037-
pubs.publication-statusPublished-
dc.identifier.orcidEllis, D. [0000-0002-7283-4667]-
Appears in Collections:Aurora harvest 5
Molecular and Biomedical Science publications

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