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|Title:||The genetic landscape of intellectual disability arising from chromosome X|
|Citation:||Trends in Genetics, 2009; 25(7):308-316|
|Publisher:||Elsevier Science London|
|Jozef Gécz, Cheryl Shoubridge and Mark Corbett|
|Abstract:||X-linked mental retardation (XLMR) or intellectual disability (ID) is a common, clinically complex and genetically heterogeneous disease arising from many mutations along the X chromosome. It affects between 1/600-1/1000 males and a substantial number of females. Research during the past decade has identified >90 different XLMR genes, affecting a wide range of cellular processes. Many more genes remain uncharacterized, especially for the non-syndromic XLMR forms. Currently, approximately 11% of X-chromosome genes are implicated in XLMR; however, apart from a few notable exceptions, most contribute individually to <0.1% of the total landscape, which arguably remains only about half complete. There remain many hills to climb and valleys to cross before the ID landscape is fully triangulated.|
|Keywords:||Chromosomes, Human, X|
Mental Retardation, X-Linked
|Description:||Copyright 2009 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Aurora harvest|
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