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Type: Journal article
Title: The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease
Author: Kadioglu, A.
Weiser, J.
Paton, J.
Andrew, P.
Citation: Nature Reviews. Microbiology, 2008; 6(4):288-301
Publisher: Nature Publishing Group
Issue Date: 2008
ISSN: 1740-1526
Statement of
Aras Kadioglu, Jeffrey N. Weiser, James C. Paton and Peter W. Andrew
Abstract: Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the mucosal surfaces of the host nasopharynx and upper airway. Through a combination of virulence-factor activity and an ability to evade the early components of the host immune response, this organism can spread from the upper respiratory tract to the sterile regions of the lower respiratory tract, which leads to pneumonia. In this Review, we describe how S. pneumoniae uses its armamentarium of virulence factors to colonize the upper and lower respiratory tracts of the host and cause disease.
Keywords: Respiratory System; Nasopharynx; Animals; Humans; Streptococcus pneumoniae; Pneumococcal Infections; Respiratory Tract Infections; Virulence Factors; Virulence
RMID: 0020080343
DOI: 10.1038/nrmicro1871
Appears in Collections:Molecular and Biomedical Science publications

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