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|Title:||Gastric emptying and the organization of antro-duodenal pressures in the critically ill|
|Citation:||Neurogastroenterology and Motility, 2008; 20(1):27-35|
|Publisher:||Blackwell Publishing Ltd|
|M. J. Chapman, R. J. Fraser, L. K. Bryant, R. Vozzo, N. Q. Nguyen, W. Tam, B. Zacharakis, G. Davidson,R. Butler & M. Horowitz|
|Abstract:||The motor dysfunctions underlying delayed gastric emptying (GE) in critical illness are poorly defined. Our aim was to characterize the relationship between antro-duodenal (AD) motility and GE in critically ill patients. AD pressures were recorded in 15 mechanically ventilated patients and 10 healthy volunteers for 2 h (i) during fasting, (ii) following an intragastric nutrient bolus with concurrent assessment of GE using the (13)C-octanoate breath test and (iii) during duodenal nutrient infusion. Propagated waves were characterized by length and direction of migration. Critical illness was associated with: (i) slower GE (GEC: 3.47 +/- 0.1 vs 2.99 +/- 0.2; P = 0.046), (ii) fewer antegrade (duodenal: 44%vs 83%, AD: 16%vs 83%; P < 0.001) and more retrograde (duodenal: 46%vs 12%, AD: 38%vs 4%; P < 0.001) waves, (iii) shorter wave propagation (duodenal: 4.7 +/- 0.3 vs 6.0 +/- 0.4 cm; AD: 7.7 +/- 0.6 vs 10.9 +/- 0.9 cm; P = 0.004) and (iv) a close correlation between GE with the percentage of propagated phase 3 waves that were antegrade (r = 0.914, P = 0.03) and retrograde (r = -0.95, P = 0.014). In critical illness, the organization of AD pressure waves is abnormal and associated with slow GE.|
|Keywords:||gastrointestinal motility; intensive care; manometry; propagated pressure waves|
|Appears in Collections:||Medicine publications|
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