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dc.contributor.authorChapman, M.en
dc.contributor.authorFraser, R.en
dc.contributor.authorBryant, L.en
dc.contributor.authorYandell, R.en
dc.contributor.authorNguyen, Q.en
dc.contributor.authorTam, W.en
dc.contributor.authorZacharakis, B.en
dc.contributor.authorDavidson, G.en
dc.contributor.authorButler, R.en
dc.contributor.authorHorowitz, M.en
dc.identifier.citationNeurogastroenterology and Motility, 2008; 20(1):27-35en
dc.description.abstractThe motor dysfunctions underlying delayed gastric emptying (GE) in critical illness are poorly defined. Our aim was to characterize the relationship between antro-duodenal (AD) motility and GE in critically ill patients. AD pressures were recorded in 15 mechanically ventilated patients and 10 healthy volunteers for 2 h (i) during fasting, (ii) following an intragastric nutrient bolus with concurrent assessment of GE using the (13)C-octanoate breath test and (iii) during duodenal nutrient infusion. Propagated waves were characterized by length and direction of migration. Critical illness was associated with: (i) slower GE (GEC: 3.47 +/- 0.1 vs 2.99 +/- 0.2; P = 0.046), (ii) fewer antegrade (duodenal: 44%vs 83%, AD: 16%vs 83%; P < 0.001) and more retrograde (duodenal: 46%vs 12%, AD: 38%vs 4%; P < 0.001) waves, (iii) shorter wave propagation (duodenal: 4.7 +/- 0.3 vs 6.0 +/- 0.4 cm; AD: 7.7 +/- 0.6 vs 10.9 +/- 0.9 cm; P = 0.004) and (iv) a close correlation between GE with the percentage of propagated phase 3 waves that were antegrade (r = 0.914, P = 0.03) and retrograde (r = -0.95, P = 0.014). In critical illness, the organization of AD pressure waves is abnormal and associated with slow GE.en
dc.description.statementofresponsibilityM. J. Chapman, R. J. Fraser, L. K. Bryant, R. Vozzo, N. Q. Nguyen, W. Tam, B. Zacharakis, G. Davidson,R. Butler & M. Horowitzen
dc.publisherBlackwell Publishing Ltden
dc.subjectgastrointestinal motility; intensive care; manometry; propagated pressure wavesen
dc.titleGastric emptying and the organization of antro-duodenal pressures in the critically illen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
Appears in Collections:Medicine publications

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