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Type: Journal article
Title: Effect of itopride on gastric emptying in longstanding diabetes mellitus
Author: Stevens, J.
Russo, A.
Maddox, A.
Rayner, C.
Phillips, L.
Talley, N.
Giguere, M.
Horowitz, M.
Jones, K.
Citation: Neurogastroenterology and Motility, 2008; 20(5):456-463
Publisher: Blackwell Publishing Ltd
Issue Date: 2008
ISSN: 1350-1925
1365-2982
Statement of
Responsibility: 
J. E. Stevens, A. Russo, A. F. Maddox, C. K. Rayner, L. Phillips, N. J. Talley, M. Giguère, M. Horowitz & K. L. Jones
Abstract: Delayed gastric emptying (GE) occurs in 30–50% of patients with longstanding type 1 or 2 diabetes, and represents a major cause of morbidity. Current therapeutic options are limited. We aimed at evaluating the effects of itopride on GE in patients with longstanding diabetes. Twenty-five patients (20 type 1, 5 type 2; 10 males, 15 females; mean age 45.2 ± 2.7 years; body mass index 27.5 ± 0.9 kg m−2; duration of diabetes 20.2 ± 2.4 years) were enrolled in a double-blind, placebo-controlled, randomized, crossover trial. Subjects received both itopride (200 mg) and placebo t.i.d. for 7 days, with a washout of 7–14 days. GE (scintigraphy), blood glucose (glucometer) and upper gastrointestinal (GI) symptoms (questionnaire) were measured following each treatment period. The test meal comprised 100 g ground beef (99mTc-sulphur colloid) and 150 mL of 10% dextrose [67Ga-ethylenediaminetetraacetic acid (EDTA)]. There was a slight trend for itopride to accelerate both solid (P = 0.09) and liquid (P = 0.09) GE. With itopride treatment, the emptying of both solids and liquids tended to be more accelerated, as the emptying with placebo was slower (solids: r = 0.39, P = 0.057; liquids: r = 0.44, P < 0.03). Twelve (48%) patients had delayed solid and/or liquid GE on placebo and in this group, itopride modestly accelerated liquid (P < 0.05), but not solid (P = 0.39), emptying. Itopride had no effect on mean blood glucose during the GE measurement (placebo: 9.8 ± 0.6 mmol L−1vs itopride: 9.6 ±0.6 mmol L−1), or GI symptoms (placebo: 1.4 ± 0.4 vs itopride: 1.8 ± 0.5). Itopride, in a dose of 200 mg t.i.d. for 7 days, tends to accelerate GE of liquids and solids in longstanding diabetes. The magnitude of this effect appears to be modest and possibly dependent on the rate of GE without itopride.
Keywords: diabetes; gastric emptying; itopride
Description: Article first published online: 7 JAN 2008
Rights: © 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd
RMID: 0020080012
DOI: 10.1111/j.1365-2982.2007.01058.x
Appears in Collections:Medicine publications

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