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dc.contributor.authorGilchrist, R.-
dc.contributor.authorLane, M.-
dc.contributor.authorThompson, J.-
dc.identifier.citationHuman Reproduction Update, 2008; 14(2):159-177-
dc.descriptionCopyright © The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.-
dc.description.abstractOocyte quality is a key limiting factor in female fertility, yet we have a poor understanding of what constitutes oocyte quality or the mechanisms governing it. The ovarian follicular microenvironment and maternal signals, mediated primarily through granulosa cells (GCs) and cumulus cells (CCs), are responsible for nurturing oocyte growth, development and the gradual acquisition of oocyte developmental competence. However, oocyte–GC/CC communication is bidirectional with the oocyte secreting potent growth factors that act locally to direct the differentiation and function of CCs. Two important oocyte-secreted factors (OSFs) are growth-differentiation factor 9 and bone morphogenetic protein 15, which activate signaling pathways in CCs to regulate key genes and cellular processes required for CC differentiation and for CCs to maintain their distinctive phenotype. Hence, oocytes appear to tightly control their neighboring somatic cells, directing them to perform functions required for appropriate development of the oocyte. This oocyte–CC regulatory loop and the capacity of oocytes to regulate their own microenvironment by OSFs may constitute important components of oocyte quality. In support of this notion, it has recently been demonstrated that supplementing oocyte in vitro maturation (IVM) media with exogenous OSFs improves oocyte developmental potential, as evidenced by enhanced pre- and post-implantation embryo development. This new perspective on oocyte–CC interactions is improving our knowledge of the processes regulating oocyte quality, which is likely to have a number of applications, including improving the efficiency of clinical IVM and thereby providing new options for the treatment of infertility.-
dc.description.statementofresponsibilityRobert B. Gilchrist, Michelle Lane and Jeremy G. Thompson-
dc.publisherOxford Univ Press-
dc.subjectIntercellular Signaling Peptides and Proteins-
dc.subjectFertilization in Vitro-
dc.subjectParacrine Communication-
dc.subjectCumulus Cells-
dc.subjectGrowth Differentiation Factor 9-
dc.subjectBone Morphogenetic Protein 15-
dc.titleOocyte-secreted factors: regulators of cumulus cell function and oocyte quality-
dc.typeJournal article-
dc.identifier.orcidGilchrist, R. [0000-0003-1611-7142]-
dc.identifier.orcidThompson, J. [0000-0003-4941-7731]-
Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

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