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Type: Journal article
Title: Hematopoietic growth factor mimetics: From concept to clinic
Author: Perugini, M.
Varelias, A.
Sadlon, T.
D'Andrea, R.
Citation: Cytokine and Growth Factor Reviews, 2009; 20(1):87-94
Publisher: Elsevier Sci Ltd
Issue Date: 2009
ISSN: 1359-6101
Statement of
Michelle Perugini, Antiopi Varelias, Timothy Sadlon and Richard J. D’Andrea
Abstract: Hematopoietic growth factor (HGF) mimetics offer a number of attractive advantages as therapeutic agents. Small chemical compounds, in particular, provide reduced cost and oral availability. As many of these mimetics are unrelated in structure to the normal cytokine the immunogenic response is not a significant issue. Isolation of small peptide agonists for erythropoietin (EPO) and thrombopoietin (TPO) receptors has been associated with significant translational challenges and here we summarize approaches used to achieve the potency and stability required for clinical utility. We also compare and contrast the initial screening approaches, and the translational and clinical issues associated with two recently approved TPO mimetics, romiplostim and the orally available eltrombopag. Finally we summarize the development and clinical findings for the EPO mimetic, Hematide, consider alternative approaches, and discuss the future potential for isolation of growth factor (GF) mimetics.
Keywords: Animals
Purpura, Thrombocytopenic, Idiopathic
Polyethylene Glycols
Carrier Proteins
Receptors, Erythropoietin
Receptors, Fc
Recombinant Fusion Proteins
Hematopoietic Cell Growth Factors
Drug Evaluation, Preclinical
Drug Design
Chemistry, Pharmaceutical
Receptors, Thrombopoietin
DOI: 10.1016/j.cytogfr.2009.01.002
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Appears in Collections:Aurora harvest 5
Paediatrics publications

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