Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/51525
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dc.contributor.authorPerugini, M.-
dc.contributor.authorVarelias, A.-
dc.contributor.authorSadlon, T.-
dc.contributor.authorD'Andrea, R.-
dc.date.issued2009-
dc.identifier.citationCytokine and Growth Factor Reviews, 2009; 20(1):87-94-
dc.identifier.issn1359-6101-
dc.identifier.issn1879-0305-
dc.identifier.urihttp://hdl.handle.net/2440/51525-
dc.description.abstractHematopoietic growth factor (HGF) mimetics offer a number of attractive advantages as therapeutic agents. Small chemical compounds, in particular, provide reduced cost and oral availability. As many of these mimetics are unrelated in structure to the normal cytokine the immunogenic response is not a significant issue. Isolation of small peptide agonists for erythropoietin (EPO) and thrombopoietin (TPO) receptors has been associated with significant translational challenges and here we summarize approaches used to achieve the potency and stability required for clinical utility. We also compare and contrast the initial screening approaches, and the translational and clinical issues associated with two recently approved TPO mimetics, romiplostim and the orally available eltrombopag. Finally we summarize the development and clinical findings for the EPO mimetic, Hematide, consider alternative approaches, and discuss the future potential for isolation of growth factor (GF) mimetics.-
dc.description.statementofresponsibilityMichelle Perugini, Antiopi Varelias, Timothy Sadlon and Richard J. D’Andrea-
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/868/description#description-
dc.language.isoen-
dc.publisherElsevier Sci Ltd-
dc.source.urihttp://dx.doi.org/10.1016/j.cytogfr.2009.01.002-
dc.subjectAnimals-
dc.subjectHumans-
dc.subjectPurpura, Thrombocytopenic, Idiopathic-
dc.subjectPolyethylene Glycols-
dc.subjectPeptides-
dc.subjectCarrier Proteins-
dc.subjectThrombopoietin-
dc.subjectReceptors, Erythropoietin-
dc.subjectReceptors, Fc-
dc.subjectRecombinant Fusion Proteins-
dc.subjectHematopoietic Cell Growth Factors-
dc.subjectCytokines-
dc.subjectDrug Evaluation, Preclinical-
dc.subjectDrug Design-
dc.subjectChemistry, Pharmaceutical-
dc.subjectReceptors, Thrombopoietin-
dc.titleHematopoietic growth factor mimetics: From concept to clinic-
dc.typeJournal article-
dc.identifier.doi10.1016/j.cytogfr.2009.01.002-
pubs.publication-statusPublished-
dc.identifier.orcidSadlon, T. [0000-0002-4821-2462]-
Appears in Collections:Aurora harvest 5
Paediatrics publications

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