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Type: Journal article
Title: Hepatitis C virus infection in South Australian prisoners: seroprevalence, seroconversion, and risk factors
Author: Miller, E.
Bi, P.
Ryan, P.
Citation: International Journal of Infectious Diseases, 2009; 13(2):201-208
Publisher: Elsevier Ltd.
Issue Date: 2009
ISSN: 1201-9712
Statement of
Emma Ruth Miller, Peng Bi and Philip Ryan
Abstract: <h4>Objectives</h4>To determine entry antibody seroprevalence and seroconversion to hepatitis C virus (HCV) and associated risk factors in newly incarcerated prisoners.<h4>Methods</h4>Males and females entering South Australian prisons completed risk factor surveys and were offered HCV-antibody testing. Participants completed additional surveys and, if HCV-negative at last test, underwent further antibody tests at 3-monthly intervals for up to 15 months. Data were analyzed using univariate and multivariate techniques.<h4>Results</h4>HCV seroprevalence among 662 prison entrants was estimated at 42%. Previous injecting history was highly prevalent at entry (64%) and both community and prison injecting independently predicted entry HCV status. Tattooing was not an important risk factor. While community exposure could not be ruled out, three seroconversions were noted in 148 initially HCV-seronegative individuals occurring in a median 121 days--4.6 per 100 person-years. Prison injecting was infrequently reported, but HCV-seropositive participants were significantly more likely to commence IDU in prison than seronegative participants (p=0.035).<h4>Conclusions</h4>Entry HCV seroprevalence in South Australian prisoners is extremely high and may have contributed to a 'ceiling effect', minimizing the observable seroconversion rate. Greater frequency of injecting among those already infected with HCV represents a significant threat to other prisoners and prison staff.
Keywords: Humans
Hepatitis C
Substance Abuse, Intravenous
Hepatitis C Antibodies
Population Surveillance
Risk Factors
Seroepidemiologic Studies
South Australia
Young Adult
Surveys and Questionnaires
DOI: 10.1016/j.ijid.2008.06.011
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Appears in Collections:Aurora harvest
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