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Type: Journal article
Title: Turn me on: regulating HIF transcriptional activity
Author: Lisy, K.
Peet, D.
Citation: Cell Death and Differentiation, 2008; 15(4):642-649
Publisher: Nature Publishing Group
Issue Date: 2008
ISSN: 1350-9047
Statement of
K Lisy and D J Peet
Abstract: The hypoxia-inducible factors (HIFs) are critical for cellular adaptation to limiting oxygen and regulate a wide array of genes when cued by cellular oxygen-sensing mechanisms. HIF is able to direct transcription from either of two transactivation domains, each of which is regulated by distinct mechanisms. The oxygen-dependent asparaginyl hydroxylase factor-inhibiting HIF-1 (FIH-1) is a key regulator of the HIF C-terminal transactivation domain, and provides a direct link between oxygen sensation and HIF-mediated transcription. Additionally, there are phosphorylation and nitrosylation events reported to modulate HIF transcriptional activity, as well as numerous transcriptional coactivators and other interacting proteins that together provide cell and tissue specificity of HIF target gene regulation.
Keywords: HIF
DOI: 10.1038/sj.cdd.4402315
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Appears in Collections:Aurora harvest 5
Molecular and Biomedical Science publications

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