Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/51669
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLisy, K.en
dc.contributor.authorPeet, D.en
dc.date.issued2008en
dc.identifier.citationCell Death and Differentiation, 2008; 15(4):642-649en
dc.identifier.issn1350-9047en
dc.identifier.issn1476-5403en
dc.identifier.urihttp://hdl.handle.net/2440/51669-
dc.description.abstractThe hypoxia-inducible factors (HIFs) are critical for cellular adaptation to limiting oxygen and regulate a wide array of genes when cued by cellular oxygen-sensing mechanisms. HIF is able to direct transcription from either of two transactivation domains, each of which is regulated by distinct mechanisms. The oxygen-dependent asparaginyl hydroxylase factor-inhibiting HIF-1 (FIH-1) is a key regulator of the HIF C-terminal transactivation domain, and provides a direct link between oxygen sensation and HIF-mediated transcription. Additionally, there are phosphorylation and nitrosylation events reported to modulate HIF transcriptional activity, as well as numerous transcriptional coactivators and other interacting proteins that together provide cell and tissue specificity of HIF target gene regulation.en
dc.description.statementofresponsibilityK Lisy and D J Peeten
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.subjectHIF; hypoxia; transcription; FIH-1; oxygenen
dc.titleTurn me on: regulating HIF transcriptional activityen
dc.typeJournal articleen
dc.identifier.doi10.1038/sj.cdd.4402315en
pubs.publication-statusPublisheden
dc.identifier.orcidLisy, K. [0000-0003-2604-4290]en
dc.identifier.orcidPeet, D. [0000-0002-6085-8936]en
Appears in Collections:Molecular and Biomedical Science publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.