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Type: Journal article
Title: D-Leu-L-Phe-containing dipeptide inhibitors of -chymosrypsin- the role of the N- and C-termini in enzyme affinity
Author: Pearson, D.
Abell, A.
Citation: ARKIVOC, 2008; 2008(12):85-93
Publisher: Arkat USA, Inc.
Issue Date: 2008
ISSN: 1551-7004
Statement of
David Pearson and Andrew D. Abell
Abstract: Three new compounds (3-5) based on a dipeptide non-covalent inhibitor (1) of α-chymotrypsin have been synthesised and assayed against the serine protease α-chymotrypsin. The stability of the compounds to α-chymotrypsin catalysed hydrolysis has been measured. All three compounds were inactive with a retained stability to enzyme catalysed hydrolysis.
Keywords: Chymotrypsin; enzyme inhibitors; peptidomimetics; azobenzene
RMID: 0020085051
DOI: 10.3998/ark.5550190.0009.c10
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Appears in Collections:Chemistry and Physics publications

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