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|Scopus||Web of Science®||Altmetric|
|Title:||D-Leu-L-Phe-containing dipeptide inhibitors of -chymosrypsin- the role of the N- and C-termini in enzyme affinity|
|Citation:||ARKIVOC, 2008; 2008(12):85-93|
|Publisher:||Arkat USA, Inc.|
|David Pearson and Andrew D. Abell|
|Abstract:||Three new compounds (3-5) based on a dipeptide non-covalent inhibitor (1) of α-chymotrypsin have been synthesised and assayed against the serine protease α-chymotrypsin. The stability of the compounds to α-chymotrypsin catalysed hydrolysis has been measured. All three compounds were inactive with a retained stability to enzyme catalysed hydrolysis.|
|Keywords:||Chymotrypsin; enzyme inhibitors; peptidomimetics; azobenzene|
|Appears in Collections:||Chemistry and Physics publications|
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