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Type: Journal article
Title: Integrating ancillary studies in a large clinical trial: the design and rationale of the APEX library
Author: Mahaffey, Kenneth
Reist, Craig J.
Fu, Yuling
Brener, Sorin J.
Theroux, Pierre
Patel, Manesh R.
Stebbins, Amanda
Westerhout, Cynthia M.
Todaro, Thomas G.
Adams, Peter X.
Granger, Christopher B.
Armstrong, Paul W.
Citation: Contemporary Clinical Trials, 2008; 29(6):887-895
Publisher: Elsevier Science Inc
Issue Date: 2008
ISSN: 1551-7144
School/Discipline: School of Medicine
Statement of
Kenneth W. Mahaffey, Craig J. Reist, Yuling Fu, Sorin J. Brener, Pierre Theroux, Manesh R. Patel, Amanda Stebbins, Cynthia M. Westerhout, Thomas G. Todaro, Peter X. Adams, Christopher B. Granger, Paul W. Armstrong, on behalf of the APEX Library Study Investigators
Abstract: The APEX library was a coordinated and integrated set of ancillary analyses and substudies that were a part of the large APEX-AMI trial. The library included electrocardiogram, angiographic, blood biomarker, genetics, and MRI components. Operationally, the goals and administration of the APEX library were developed concurrently with the design of the parent trial. The goal recruitment in the library was met due to this approach. These data will provide important insights into the pathobiology of acute myocardial infarction and the relationships between inflammation, thrombosis, genetics, and classic clinical markers from angiograms, electrocardiograms, and patient demographics. In conclusion, the APEX library is an example of successful collaboration among academic trial leaders, site investigators, and pharmaceutical sponsors. The operational paradigm of this effort should be considered in future investigations so that important advances in clinical care of disease can be realized efficiently.
Keywords: Clinical trials; Library substudy
Description: Copyright © 2008 Elsevier B.V. All rights reserved. ScienceDirect® is a registered trademark of Elsevier B.V.
RMID: 0020085735
DOI: 10.1016/j.cct.2008.06.003
Appears in Collections:Medicine publications

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