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Type: Journal article
Title: Immunomodulatory mast cells: Negative, as well as positive, regulators of immunity
Author: Galli, S.
Grimbaldeston, M.
Tsai, M.
Citation: Nature Reviews Immunology, 2008; 8(6):478-486
Publisher: Nature Publishing Group
Issue Date: 2008
ISSN: 1474-1733
Statement of
Stephen J. Galli, Michele Grimbaldeston and Mindy Tsai
Abstract: Mast cells can promote inflammation and other tissue changes in IgE-associated allergic disorders, as well as in certain innate and adaptive immune responses that are thought to be independent of IgE. However, mast cells can also have anti-inflammatory and immunosuppressive functions. Here, we review the evidence that mast cells can have negative, as well as positive, immunomodulatory roles in vivo, and we propose that mast cells can both enhance and later suppress certain features of an immune response.
Keywords: Mast Cells
Disease Models, Animal
Inflammation Mediators
Immunologic Factors
Immunity, Cellular
Description: © 2008 Nature Publishing Group, a division of Macmillan Publishers Limited.
DOI: 10.1038/nri2327
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Appears in Collections:Aurora harvest
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