Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/51885
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Type: Journal article
Title: Immunomodulatory mast cells: Negative, as well as positive, regulators of immunity
Author: Galli, S.
Grimbaldeston, M.
Tsai, M.
Citation: Nature Reviews. Immunology, 2008; 8(6):478-486
Publisher: Nature Publishing Group
Issue Date: 2008
ISSN: 1474-1733
1474-1741
Statement of
Responsibility: 
Stephen J. Galli, Michele Grimbaldeston and Mindy Tsai
Abstract: Mast cells can promote inflammation and other tissue changes in IgE-associated allergic disorders, as well as in certain innate and adaptive immune responses that are thought to be independent of IgE. However, mast cells can also have anti-inflammatory and immunosuppressive functions. Here, we review the evidence that mast cells can have negative, as well as positive, immunomodulatory roles in vivo, and we propose that mast cells can both enhance and later suppress certain features of an immune response.
Keywords: Mast Cells; Animals; Humans; Disease Models, Animal; Inflammation Mediators; Immunologic Factors; Immunity, Cellular
Description: © 2008 Nature Publishing Group, a division of Macmillan Publishers Limited.
RMID: 0020083756
DOI: 10.1038/nri2327
Appears in Collections:Medicine publications

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