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Type: Journal article
Title: Concise review: Mesenchymal stromal cells: Potential for cardiovascular repair
Author: Psaltis, P.
Zannettino, A.
Worthley, S.
Gronthos, S.
Citation: Stem Cells, 2008; 26(9):2201-2210
Publisher: Alphamed Press
Issue Date: 2008
ISSN: 1066-5099
Statement of
Peter J. Psaltis, Andrew C.W. Zannettino, Stephen G. Worthley, Stan Gronthos
Abstract: Cellular therapy for cardiovascular disease heralds an exciting frontier of research. Mesenchymal stromal cells (MSCs) are present in adult tissues, including bone marrow and adipose, from which they can be easily isolated and cultured ex vivo. Although traditional isolation of these cells by plastic adherence results in a heterogeneous composite of mature and immature cell types, MSCs do possess plasticity of differentiation and under appropriate in vitro culture conditions can be modified to adopt cardiomyocyte and vascular cell phenotypic characteristics. In vivo preclinical studies have demonstrated their capacity to facilitate both myocardial repair and neovascularization in models of cardiac injury. The mechanisms underlying these effects appear to be mediated predominantly through indirect paracrine actions, rather than direct regeneration of endogenous cells by transdifferentiation, especially because current transplantation strategies achieve only modest engraftment of cells in the host myocardium. Currently, published clinical trial experience of MSCs as cardiac therapy is limited, and the outcomes of ongoing studies are keenly anticipated. Of relevance to clinical application is the fact that MSCs are relatively immunoprivileged, potentially enabling their allogeneic therapeutic use, although this too requires further investigation. Overall, MSCs are an attractive adult-derived cell population for cardiovascular repair; however, research is still required at both basic and clinical levels to resolve critical areas of uncertainty and to ensure continued development in cell culture engineering and cell transplantation technology.
Keywords: Bone Marrow Cells; Adipocytes; Stromal Cells; Myocytes, Cardiac; Mesenchymal Stem Cells; Humans; Cardiovascular Diseases; Mesenchymal Stem Cell Transplantation; Cell Separation; Cell Differentiation; Adult Stem Cells
Description: The definitive version may be found at
RMID: 0020082728
DOI: 10.1634/stemcells.2008-0428
Appears in Collections:Medicine publications

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